Cargando…
Influence of estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness
To determine the effects of the estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on dietary advice-mediated changes in fasting glucose and arterial stiffness, 374 subjects with normal fasting glucose (NFG; control group, no treatment) and 142 subjects with impaired fasting glucose...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575041/ https://www.ncbi.nlm.nih.gov/pubmed/28852080 http://dx.doi.org/10.1038/s41598-017-10192-6 |
_version_ | 1783259958436954112 |
---|---|
author | Kim, Minjoo Yoo, Hye Jin Kim, Minkyung Seo, Haengok Chae, Jey Sook Lee, Sang-Hyun Lee, Jong Ho |
author_facet | Kim, Minjoo Yoo, Hye Jin Kim, Minkyung Seo, Haengok Chae, Jey Sook Lee, Sang-Hyun Lee, Jong Ho |
author_sort | Kim, Minjoo |
collection | PubMed |
description | To determine the effects of the estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on dietary advice-mediated changes in fasting glucose and arterial stiffness, 374 subjects with normal fasting glucose (NFG; control group, no treatment) and 142 subjects with impaired fasting glucose (IFG group, dietary advice) were followed for 3.5 years. At follow-up, the GG subjects in the IFG group showed a significant reduction in fasting glucose, which was greater than in the AA subjects. A significant association was observed between ESRRG rs1890552 A > G polymorphism and changes in fasting glucose, brachial-ankle pulse wave velocity (ba-PWV), and 8-epi-prostaglandin F(2α) in the IFG subjects. At baseline, the GG subjects showed a higher ba-PWV than the AA subjects in the IFG group. At the 3.5-year follow-up, subjects with AA or AG showed significant increases in ba-PWV, whereas subjects with GG showed a decrease from baseline. This study suggests that the ESRRG rs1890552 A > G polymorphism may modulate interindividual differences in atrial stiffness, with a reduction in fasting glucose in response to dietary advice in subjects with IFG after a 3.5-year follow-up. |
format | Online Article Text |
id | pubmed-5575041 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-55750412017-09-01 Influence of estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness Kim, Minjoo Yoo, Hye Jin Kim, Minkyung Seo, Haengok Chae, Jey Sook Lee, Sang-Hyun Lee, Jong Ho Sci Rep Article To determine the effects of the estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on dietary advice-mediated changes in fasting glucose and arterial stiffness, 374 subjects with normal fasting glucose (NFG; control group, no treatment) and 142 subjects with impaired fasting glucose (IFG group, dietary advice) were followed for 3.5 years. At follow-up, the GG subjects in the IFG group showed a significant reduction in fasting glucose, which was greater than in the AA subjects. A significant association was observed between ESRRG rs1890552 A > G polymorphism and changes in fasting glucose, brachial-ankle pulse wave velocity (ba-PWV), and 8-epi-prostaglandin F(2α) in the IFG subjects. At baseline, the GG subjects showed a higher ba-PWV than the AA subjects in the IFG group. At the 3.5-year follow-up, subjects with AA or AG showed significant increases in ba-PWV, whereas subjects with GG showed a decrease from baseline. This study suggests that the ESRRG rs1890552 A > G polymorphism may modulate interindividual differences in atrial stiffness, with a reduction in fasting glucose in response to dietary advice in subjects with IFG after a 3.5-year follow-up. Nature Publishing Group UK 2017-08-29 /pmc/articles/PMC5575041/ /pubmed/28852080 http://dx.doi.org/10.1038/s41598-017-10192-6 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kim, Minjoo Yoo, Hye Jin Kim, Minkyung Seo, Haengok Chae, Jey Sook Lee, Sang-Hyun Lee, Jong Ho Influence of estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness |
title | Influence of estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness |
title_full | Influence of estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness |
title_fullStr | Influence of estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness |
title_full_unstemmed | Influence of estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness |
title_short | Influence of estrogen-related receptor γ (ESRRG) rs1890552 A > G polymorphism on changes in fasting glucose and arterial stiffness |
title_sort | influence of estrogen-related receptor γ (esrrg) rs1890552 a > g polymorphism on changes in fasting glucose and arterial stiffness |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575041/ https://www.ncbi.nlm.nih.gov/pubmed/28852080 http://dx.doi.org/10.1038/s41598-017-10192-6 |
work_keys_str_mv | AT kimminjoo influenceofestrogenrelatedreceptorgesrrgrs1890552agpolymorphismonchangesinfastingglucoseandarterialstiffness AT yoohyejin influenceofestrogenrelatedreceptorgesrrgrs1890552agpolymorphismonchangesinfastingglucoseandarterialstiffness AT kimminkyung influenceofestrogenrelatedreceptorgesrrgrs1890552agpolymorphismonchangesinfastingglucoseandarterialstiffness AT seohaengok influenceofestrogenrelatedreceptorgesrrgrs1890552agpolymorphismonchangesinfastingglucoseandarterialstiffness AT chaejeysook influenceofestrogenrelatedreceptorgesrrgrs1890552agpolymorphismonchangesinfastingglucoseandarterialstiffness AT leesanghyun influenceofestrogenrelatedreceptorgesrrgrs1890552agpolymorphismonchangesinfastingglucoseandarterialstiffness AT leejongho influenceofestrogenrelatedreceptorgesrrgrs1890552agpolymorphismonchangesinfastingglucoseandarterialstiffness |