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The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications
Hemorrhagic stroke, accounting for 10–30% of stroke cases, carries high rates of morbidity and mortality. This review presents the current knowledge on the efficacy of hyperbaric oxygen (HBO)-based modalities in the preclinical research on hemorrhagic stroke. Both preconditioning and post-treatment...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575217/ https://www.ncbi.nlm.nih.gov/pubmed/28883864 http://dx.doi.org/10.5114/aoms.2017.65081 |
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author | Ostrowski, Robert P. Stępień, Katarzyna Pucko, Emanuela Matyja, Ewa |
author_facet | Ostrowski, Robert P. Stępień, Katarzyna Pucko, Emanuela Matyja, Ewa |
author_sort | Ostrowski, Robert P. |
collection | PubMed |
description | Hemorrhagic stroke, accounting for 10–30% of stroke cases, carries high rates of morbidity and mortality. This review presents the current knowledge on the efficacy of hyperbaric oxygen (HBO)-based modalities in the preclinical research on hemorrhagic stroke. Both preconditioning and post-treatment with HBO are considered as prospective therapeutic options. High efficacy of HBO therapy (HBOT) for brain hemorrhage has been noted. We found that moderate hyperbaric pressures appear optimal for therapeutic effect, while the therapeutic window of opportunity is short. HBO preconditioning offers more modest neuroprotective benefit as compared to HBO post-treatment for experimental intracerebral hemorrhage. We advocate for mandatory calculations of percent changes in the experimentally investigated indexes of HBO effectiveness and stress the need to design new clinical trials on HBO for hemorrhagic stroke. |
format | Online Article Text |
id | pubmed-5575217 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-55752172017-09-07 The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications Ostrowski, Robert P. Stępień, Katarzyna Pucko, Emanuela Matyja, Ewa Arch Med Sci State of the Art Paper Hemorrhagic stroke, accounting for 10–30% of stroke cases, carries high rates of morbidity and mortality. This review presents the current knowledge on the efficacy of hyperbaric oxygen (HBO)-based modalities in the preclinical research on hemorrhagic stroke. Both preconditioning and post-treatment with HBO are considered as prospective therapeutic options. High efficacy of HBO therapy (HBOT) for brain hemorrhage has been noted. We found that moderate hyperbaric pressures appear optimal for therapeutic effect, while the therapeutic window of opportunity is short. HBO preconditioning offers more modest neuroprotective benefit as compared to HBO post-treatment for experimental intracerebral hemorrhage. We advocate for mandatory calculations of percent changes in the experimentally investigated indexes of HBO effectiveness and stress the need to design new clinical trials on HBO for hemorrhagic stroke. Termedia Publishing House 2017-01-13 2017-08 /pmc/articles/PMC5575217/ /pubmed/28883864 http://dx.doi.org/10.5114/aoms.2017.65081 Text en Copyright: © 2017 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | State of the Art Paper Ostrowski, Robert P. Stępień, Katarzyna Pucko, Emanuela Matyja, Ewa The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications |
title | The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications |
title_full | The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications |
title_fullStr | The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications |
title_full_unstemmed | The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications |
title_short | The efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications |
title_sort | efficacy of hyperbaric oxygen in hemorrhagic stroke: experimental and clinical implications |
topic | State of the Art Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575217/ https://www.ncbi.nlm.nih.gov/pubmed/28883864 http://dx.doi.org/10.5114/aoms.2017.65081 |
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