An allosteric ligand-binding site in the extracellular cap of K2P channels

Two-pore domain potassium (K2P) channels generate leak currents that are responsible for the maintenance of the resting membrane potential, and they are thus potential drug targets for treating diseases. Here, we identify N-(4-cholorphenyl)-N-(2-(3,4-dihydrosioquinolin-2(1H)-yl)-2-oxoethyl)methanesu...

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Detalles Bibliográficos
Autores principales: Luo, Qichao, Chen, Liping, Cheng, Xi, Ma, Yuqin, Li, Xiaona, Zhang, Bing, Li, Li, Zhang, Shilei, Guo, Fei, Li, Yang, Yang, Huaiyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575254/
https://www.ncbi.nlm.nih.gov/pubmed/28851868
http://dx.doi.org/10.1038/s41467-017-00499-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575254/
https://www.ncbi.nlm.nih.gov/pubmed/28851868
http://dx.doi.org/10.1038/s41467-017-00499-3

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