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A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells

A new series of etherification chalcone derivatives were designed and synthesized through Willimison etherification and Claisen-Schmidt condensation. Among them, compound 2-c which was given chemical name of S17, has been successfully screened out as the most potent one on gastric cancer cell line(M...

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Detalles Bibliográficos
Autores principales:	Zhang, Saiyang, Li, Tingyu, Zhang, Li, Wang, Xiangyu, Dong, Hangqi, Li, Lili, Fu, Dongjun, Li, Yongchun, Zi, Xiaolin, Liu, Hong-Min, Zhang, Yanbing, Xu, Hongde, Jin, Cheng-Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575266/ https://www.ncbi.nlm.nih.gov/pubmed/28852176 http://dx.doi.org/10.1038/s41598-017-10400-3

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