Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma

Follistatin-related protein 1 (FSTL1) plays a critical role in lung development through regulating BMP4-p-Smad1/5/8-Smad4 pathway. Regarding that many developmental pathways in embryogenesis are dysregulated in cancer, we aim to unravel the role of FSTL1-BMP4-Smad pathway in lung cancer. Our results...

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Detalles Bibliográficos
Autores principales: Chiou, Jean, Su, Chia-Yi, Jan, Yi-Hua, Yang, Chih-Jen, Huang, Ming-Shyan, Yu, Yung-Luen, Hsiao, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575295/
https://www.ncbi.nlm.nih.gov/pubmed/28852126
http://dx.doi.org/10.1038/s41598-017-10366-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575295/
https://www.ncbi.nlm.nih.gov/pubmed/28852126
http://dx.doi.org/10.1038/s41598-017-10366-2

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