Studies on the regulatory mechanism of isocitrate dehydrogenase 2 using acetylation mimics

Mitochondrial isocitrate dehydrogenase 2 (IDH2) converts NADP(+) to NADPH and promotes regeneration of reduced glutathione (GSH) by supplying NADPH to glutathione reductase or thioredoxin reductase. We have previously shown that under calorie restriction, mitochondrial deacetylase Sirt3 deacetylates...

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Detalles Bibliográficos
Autores principales: Xu, Yuqun, Liu, Lingwen, Nakamura, Akira, Someya, Shinichi, Miyakawa, Takuya, Tanokura, Masaru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575304/
https://www.ncbi.nlm.nih.gov/pubmed/28852116
http://dx.doi.org/10.1038/s41598-017-10337-7

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