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IRF2BP2-deficient microglia block the anxiolytic effect of enhanced postnatal care

Enhanced postnatal care (EPC) increases resilience to adversity in adulthood. Since microglia participate in shaping neural circuits, we asked how ablation of an inflammation-suppressing factor IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) in microglia would affect the responses to EPC....

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Detalles Bibliográficos
Autores principales: Hari, Aswin, Cruz, Shelly A., Qin, Zhaohong, Couture, Pascal, Vilmundarson, Ragnar O., Huang, Hua, Stewart, Alexandre F. R., Chen, Hsiao-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575313/
https://www.ncbi.nlm.nih.gov/pubmed/28852125
http://dx.doi.org/10.1038/s41598-017-10349-3