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Atp6ap2 ablation in adult mice impairs viability through multiple organ deficiencies

ATP6AP2 codes for the (pro)renin receptor and is an essential component of vacuolar H+ ATPase. Activating (pro)renin for conversion of Angiotensinogen to Angiotensin makes ATP6AP2 attractive for drug intervention. Tissue-specific ATP6AP2 inactivation in mouse suggested a strong impact on various org...

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Detalles Bibliográficos
Autores principales:	Wendling, Olivia, Champy, Marie-France, Jaubert, Solène, Pavlovic, Guillaume, Dubos, Aline, Lindner, Loic, Jacobs, Hugues, Mark, Manuel, Combe, Roy, Da Cruz, Isabelle Goncalves, Luche, Hervé, Mudgett, John S., Rosahl, Thomas, Sorg, Tania, Malissen, Marie, Reilly, Patrick T., Hérault, Yann
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575319/ https://www.ncbi.nlm.nih.gov/pubmed/28851918 http://dx.doi.org/10.1038/s41598-017-08845-7

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