Selinexor (KPT-330) has antitumor activity against anaplastic thyroid carcinoma in vitro and in vivo and enhances sensitivity to doxorubicin

Anaplastic thyroid carcinoma (ATC) is one of the most lethal malignancies having no effective treatment. Exportin-1 (XPO1) is the key mediator of nuclear export of many tumor suppressor proteins and is overexpressed in human cancers. In this study, we examined the therapeutic potential of selinexor...

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Detalles Bibliográficos
Autores principales: Garg, Manoj, Kanojia, Deepika, Mayakonda, Anand, Ganesan, Trivadi S, Sadhanandhan, Bindhya, Suresh, Sidhanth, S., Sneha, Nagare, Rohit P., Said, Jonathan W., Doan, Ngan B., Ding, Ling-Wen, Baloglu, Erkan, Shacham, Sharon, Kauffman, Michael, Koeffler, H. Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575339/
https://www.ncbi.nlm.nih.gov/pubmed/28852098
http://dx.doi.org/10.1038/s41598-017-10325-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575339/
https://www.ncbi.nlm.nih.gov/pubmed/28852098
http://dx.doi.org/10.1038/s41598-017-10325-x

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