Location of monoclonal peak as a tool in checking specimen integrity

OBJECTIVES: Serum protein electrophoresis is a commonly used test in the diagnosis and follow-up of patients with monoclonal gammopathies. The practice of documenting the location of the peak may serve as delta check flags in SPEP samples. METHODS: We report on the inconsistent finding on two tests...

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Detalles Bibliográficos
Autores principales: Vyas, Shikhar G., Singh, Gurmukh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575375/
https://www.ncbi.nlm.nih.gov/pubmed/28856227
http://dx.doi.org/10.1016/j.plabm.2017.04.005
Descripción
Sumario:OBJECTIVES: Serum protein electrophoresis is a commonly used test in the diagnosis and follow-up of patients with monoclonal gammopathies. The practice of documenting the location of the peak may serve as delta check flags in SPEP samples. METHODS: We report on the inconsistent finding on two tests performed about three months apart. The inconsistency was discovered due to recognition of the change in the location of the monoclonal immunoglobulin on protein electrophoresis. RESULTS: Repeat testing with a third specimen revealed that the first test was run on a wrong specimen. CONCLUSION: Recording the location of the monoclonal spike is recommended to serve as an additional “delta” check.

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