End stage renal disease‐induced hypercalcemia may promote aortic valve calcification via Annexin VI enrichment of valve interstitial cell derived‐matrix vesicles

Patients with end‐stage renal disease (ESRD) have elevated circulating calcium (Ca) and phosphate (Pi), and exhibit accelerated progression of calcific aortic valve disease (CAVD). We hypothesized that matrix vesicles (MVs) initiate the calcification process in CAVD. Ca induced rat valve interstitia...

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Detalles Bibliográficos
Autores principales: Cui, Lin, Rashdan, Nabil A., Zhu, Dongxing, Milne, Elspeth M., Ajuh, Paul, Milne, Gillian, Helfrich, Miep H., Lim, Kelvin, Prasad, Sai, Lerman, Daniel A., Vesey, Alex T., Dweck, Marc R., Jenkins, William S., Newby, David E., Farquharson, Colin, Macrae, Vicky E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Original Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575563/
https://www.ncbi.nlm.nih.gov/pubmed/28369848
http://dx.doi.org/10.1002/jcp.25935

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