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Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents
Non-invasive diagnosis and quantification of liver steatosis is important to overcome limits of liver biopsy, in order to follow up patients during their therapy and to establish a reference standard that can be used in clinical trials and longitudinal studies. Imaging offers several methods in this...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575595/ https://www.ncbi.nlm.nih.gov/pubmed/28800087 http://dx.doi.org/10.3390/children4080073 |
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author | Di Martino, Michele Koryukova, Kameliya Bezzi, Mario Catalano, Carlo |
author_facet | Di Martino, Michele Koryukova, Kameliya Bezzi, Mario Catalano, Carlo |
author_sort | Di Martino, Michele |
collection | PubMed |
description | Non-invasive diagnosis and quantification of liver steatosis is important to overcome limits of liver biopsy, in order to follow up patients during their therapy and to establish a reference standard that can be used in clinical trials and longitudinal studies. Imaging offers several methods in this setting: ultrasound, which is the cheapest technique and easy to perform; magnetic resonance spectroscopy (MRS), which reflects the real content of triglycerides in a specific volume; and proton density fat fraction (PDFF) magnetic resonance, which is a simple method that reflects the distribution of the fat in the whole liver. Other techniques include ultrasound elastography (EUS) and magnetic resonance elastrography (MRE), which can evaluate the progression of non-alcoholic fatty liver disease (NAFLD) into non-alcoholic steato-hepatitis (NASH) and cirrhosis, by quantifying liver fibrosis. |
format | Online Article Text |
id | pubmed-5575595 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55755952017-08-31 Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents Di Martino, Michele Koryukova, Kameliya Bezzi, Mario Catalano, Carlo Children (Basel) Review Non-invasive diagnosis and quantification of liver steatosis is important to overcome limits of liver biopsy, in order to follow up patients during their therapy and to establish a reference standard that can be used in clinical trials and longitudinal studies. Imaging offers several methods in this setting: ultrasound, which is the cheapest technique and easy to perform; magnetic resonance spectroscopy (MRS), which reflects the real content of triglycerides in a specific volume; and proton density fat fraction (PDFF) magnetic resonance, which is a simple method that reflects the distribution of the fat in the whole liver. Other techniques include ultrasound elastography (EUS) and magnetic resonance elastrography (MRE), which can evaluate the progression of non-alcoholic fatty liver disease (NAFLD) into non-alcoholic steato-hepatitis (NASH) and cirrhosis, by quantifying liver fibrosis. MDPI 2017-08-11 /pmc/articles/PMC5575595/ /pubmed/28800087 http://dx.doi.org/10.3390/children4080073 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Di Martino, Michele Koryukova, Kameliya Bezzi, Mario Catalano, Carlo Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents |
title | Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents |
title_full | Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents |
title_fullStr | Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents |
title_full_unstemmed | Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents |
title_short | Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents |
title_sort | imaging features of non-alcoholic fatty liver disease in children and adolescents |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575595/ https://www.ncbi.nlm.nih.gov/pubmed/28800087 http://dx.doi.org/10.3390/children4080073 |
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