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Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents

Non-invasive diagnosis and quantification of liver steatosis is important to overcome limits of liver biopsy, in order to follow up patients during their therapy and to establish a reference standard that can be used in clinical trials and longitudinal studies. Imaging offers several methods in this...

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Detalles Bibliográficos
Autores principales: Di Martino, Michele, Koryukova, Kameliya, Bezzi, Mario, Catalano, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575595/
https://www.ncbi.nlm.nih.gov/pubmed/28800087
http://dx.doi.org/10.3390/children4080073
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author Di Martino, Michele
Koryukova, Kameliya
Bezzi, Mario
Catalano, Carlo
author_facet Di Martino, Michele
Koryukova, Kameliya
Bezzi, Mario
Catalano, Carlo
author_sort Di Martino, Michele
collection PubMed
description Non-invasive diagnosis and quantification of liver steatosis is important to overcome limits of liver biopsy, in order to follow up patients during their therapy and to establish a reference standard that can be used in clinical trials and longitudinal studies. Imaging offers several methods in this setting: ultrasound, which is the cheapest technique and easy to perform; magnetic resonance spectroscopy (MRS), which reflects the real content of triglycerides in a specific volume; and proton density fat fraction (PDFF) magnetic resonance, which is a simple method that reflects the distribution of the fat in the whole liver. Other techniques include ultrasound elastography (EUS) and magnetic resonance elastrography (MRE), which can evaluate the progression of non-alcoholic fatty liver disease (NAFLD) into non-alcoholic steato-hepatitis (NASH) and cirrhosis, by quantifying liver fibrosis.
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spelling pubmed-55755952017-08-31 Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents Di Martino, Michele Koryukova, Kameliya Bezzi, Mario Catalano, Carlo Children (Basel) Review Non-invasive diagnosis and quantification of liver steatosis is important to overcome limits of liver biopsy, in order to follow up patients during their therapy and to establish a reference standard that can be used in clinical trials and longitudinal studies. Imaging offers several methods in this setting: ultrasound, which is the cheapest technique and easy to perform; magnetic resonance spectroscopy (MRS), which reflects the real content of triglycerides in a specific volume; and proton density fat fraction (PDFF) magnetic resonance, which is a simple method that reflects the distribution of the fat in the whole liver. Other techniques include ultrasound elastography (EUS) and magnetic resonance elastrography (MRE), which can evaluate the progression of non-alcoholic fatty liver disease (NAFLD) into non-alcoholic steato-hepatitis (NASH) and cirrhosis, by quantifying liver fibrosis. MDPI 2017-08-11 /pmc/articles/PMC5575595/ /pubmed/28800087 http://dx.doi.org/10.3390/children4080073 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Di Martino, Michele
Koryukova, Kameliya
Bezzi, Mario
Catalano, Carlo
Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents
title Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents
title_full Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents
title_fullStr Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents
title_full_unstemmed Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents
title_short Imaging Features of Non-Alcoholic Fatty Liver Disease in Children and Adolescents
title_sort imaging features of non-alcoholic fatty liver disease in children and adolescents
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575595/
https://www.ncbi.nlm.nih.gov/pubmed/28800087
http://dx.doi.org/10.3390/children4080073
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