Aberrant Methylation-Mediated Suppression of APAF1 in Myelodysplastic Syndrome

Background: Myelodysplastic syndromes (MDSs) include a diverse group of clonal bone marrow disorders characterized by ineffective hematopoiesis and pancytopenia. It was found that down regulation of APAF1, a putative tumor suppressor gene (TSG), leads to resistance to chemotherapy and disease develo...

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Detalles Bibliográficos
Autores principales: Zaker, Farhad, Nasiri, Nahid, Amirizadeh, Naser, Razavi, Seyed Mohsen, Yaghmaie, Marjan, Teimoori-Toolabi, Ladan, Maleki, Ali, Bakhshayesh, Masoumeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575724/
https://www.ncbi.nlm.nih.gov/pubmed/28875006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575724/
https://www.ncbi.nlm.nih.gov/pubmed/28875006

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