Cargando…

An Aγ-globin G->A gene polymorphism associated with β(0)39 thalassemia globin gene and high fetal hemoglobin production

BACKGROUND: Increase of the expression of γ-globin gene and high production of fetal hemoglobin (HbF) in β-thalassemia patients is widely accepted as associated with a milder or even asymptomatic disease. The search for HbF-associated polymorphisms (such as the XmnI, BCL11A and MYB polymorphisms) ha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Breveglieri, Giulia, Bianchi, Nicoletta, Cosenza, Lucia Carmela, Gamberini, Maria Rita, Chiavilli, Francesco, Zuccato, Cristina, Montagner, Giulia, Borgatti, Monica, Lampronti, Ilaria, Finotti, Alessia, Gambari, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575872/ https://www.ncbi.nlm.nih.gov/pubmed/28851297 http://dx.doi.org/10.1186/s12881-017-0450-3

Ejemplares similares

The rs368698783 (G>A) Polymorphism Affecting LYAR Binding to the Aγ-Globin Gene Is Associated with High Fetal Hemoglobin (HbF) in β-Thalassemia Erythroid Precursor Cells Treated with HbF Inducers
por: Zuccato, Cristina, et al.
Publicado: (2023)

Co-Treatment of Erythroid Cells from β-Thalassemia Patients with CRISPR-Cas9-Based β(0)39-Globin Gene Editing and Induction of Fetal Hemoglobin
por: Cosenza, Lucia Carmela, et al.
Publicado: (2022)

Generation and Characterization of a Transgenic Mouse Carrying a Functional Human β-Globin Gene with the IVSI-6 Thalassemia Mutation
por: Breveglieri, Giulia, et al.
Publicado: (2015)

Expression of γ-globin genes in β-thalassemia patients treated with sirolimus: results from a pilot clinical trial (Sirthalaclin)
por: Zuccato, Cristina, et al.
Publicado: (2022)

BCL11A mRNA Targeting by miR-210: A Possible Network Regulating γ-Globin Gene Expression
por: Gasparello, Jessica, et al.
Publicado: (2017)

Peptide nucleic acids targeting β-globin mRNAs selectively inhibit hemoglobin production in murine erythroleukemia cells
por: MONTAGNER, GIULIA, et al.
Publicado: (2015)

Efficient CRISPR-Cas9-based genome editing of β-globin gene on erythroid cells from homozygous β(0)39-thalassemia patients
por: Cosenza, Lucia Carmela, et al.
Publicado: (2021)

Production and Characterization of K562 Cellular Clones Hyper-Expressing the Gene Encoding α-Globin: Preliminary Analysis of Biomarkers Associated with Autophagy
por: Zurlo, Matteo, et al.
Publicado: (2023)

A Rational Approach to Drug Repositioning in β-thalassemia: Induction of Fetal Hemoglobin by Established Drugs
por: Prosdocimi, Marco, et al.
Publicado: (2022)

A validated cellular biobank for β-thalassemia
por: Cosenza, Lucia Carmela, et al.
Publicado: (2016)

Effects of Mithramycin on BCL11A Gene Expression and on the Interaction of the BCL11A Transcriptional Complex to γ-Globin Gene Promoter Sequences
por: Finotti, Alessia, et al.
Publicado: (2023)

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction
por: Zuccato, Cristina, et al.
Publicado: (2012)

Treatment of Erythroid Precursor Cells from β-Thalassemia Patients with Cinchona Alkaloids: Induction of Fetal Hemoglobin Production
por: Zuccato, Cristina, et al.
Publicado: (2021)

Decrease in α-Globin and Increase in the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus
por: Zurlo, Matteo, et al.
Publicado: (2023)

Development and characterization of K562 cell clones expressing BCL11A-XL: Decreased hemoglobin production with fetal hemoglobin inducers and its rescue with mithramycin
por: Finotti, Alessia, et al.
Publicado: (2015)

Fetal Hemoglobin Inducers from the Natural World: A Novel Approach for Identification of Drugs for the Treatment of β-Thalassemia and Sickle-Cell Anemia
por: Bianchi, Nicoletta, et al.
Publicado: (2009)

UPF1 silenced cellular model systems for screening of read-through agents active on β(0)39 thalassemia point mutation
por: Salvatori, Francesca, et al.
Publicado: (2018)

Increase of microRNA-210, Decrease of Raptor Gene Expression and Alteration of Mammalian Target of Rapamycin Regulated Proteins following Mithramycin Treatment of Human Erythroid Cells
por: Bianchi, Nicoletta, et al.
Publicado: (2015)

Effects of Sirolimus Treatment on Fetal Hemoglobin Production and Response to SARS-CoV-2 Vaccination: A Case Report Study
por: Gamberini, Maria Rita, et al.
Publicado: (2023)

Induction of erythroid differentiation and increased globin mRNA production with furocoumarins and their photoproducts
por: Salvador, Alessia, et al.
Publicado: (2013)

Discovery of Novel Fetal Hemoglobin Inducers through Small Chemical Library Screening
por: Breveglieri, Giulia, et al.
Publicado: (2020)

Correlation of BACH1 and Hemoglobin E/Beta-Thalassemia Globin Expression
por: Lee, Tze Yan, et al.
Publicado: (2016)

Analysis of deletional hereditary persistence of fetal hemoglobin/δβ‐thalassemia and δ‐globin gene mutations in Southerwestern China
por: Zhang, Jie, et al.
Publicado: (2019)

Erythroid induction of K562 cells treated with mithramycin is associated with inhibition of raptor gene transcription and mammalian target of rapamycin complex 1 (mTORC1) functions
por: Finotti, Alessia, et al.
Publicado: (2015)

Recent trends in the gene therapy of β-thalassemia
por: Finotti, Alessia, et al.
Publicado: (2015)

5613417 CO-TREATMENT OF ERYTHROID CELLS ISOLATED FROM Β039-THALASSEMIA PATIENTS WITH CRISPR-CAS9 GENE EDITING AND FETAL HEMOGLOBIN INDUCTION
por: Lipucci di Paola, M.L.P., et al.
Publicado: (2023)

Induction of Fetal Hemoglobin by Introducing Natural Hereditary Persistence of Fetal Hemoglobin Mutations in the γ-Globin Gene Promoters for Genome Editing Therapies for β-Thalassemia
por: Lu, Dian, et al.
Publicado: (2022)

The Long Scientific Journey of Sirolimus (Rapamycin): From the Soil of Easter Island (Rapa Nui) to Applied Research and Clinical Trials on β-Thalassemia and Other Hemoglobinopathies
por: Gambari, Roberto, et al.
Publicado: (2023)

Postnatal and non-invasive prenatal detection of β-thalassemia mutations based on Taqman genotyping assays
por: Breveglieri, Giulia, et al.
Publicado: (2017)

Teaching during COVID-19 pandemic in practical laboratory classes of applied biochemistry and pharmacology: A validated fast and simple protocol for detection of SARS-CoV-2 Spike sequences
por: Gasparello, Jessica, et al.
Publicado: (2022)

Coordinated β-globin expression and α2-globin reduction in a multiplex lentiviral gene therapy vector for β-thalassemia
por: Nualkaew, Tiwaporn, et al.
Publicado: (2021)

Globin genes on the move
por: Hardison, Ross C
Publicado: (2008)

Detection of the sickle hemoglobin allele using a surface plasmon resonance based biosensor
por: Breveglieri, Giulia, et al.
Publicado: (2019)

Spectrum of Beta Globin Gene Mutations in Egyptian Children with β-Thalassemia
por: El-Shanshory, MR, et al.
Publicado: (2014)

The phenomena of balanced effect between α-globin gene and of β-globin gene
por: Zhong, Liangying, et al.
Publicado: (2018)

The globin gene family of the cephalochordate amphioxus: implications for chordate globin evolution
por: Ebner, Bettina, et al.
Publicado: (2010)

TMEM8 – a non-globin gene entrapped in the globin web
por: Philonenko, Elena S., et al.
Publicado: (2009)

β-Thalassemia Intermedia: Interaction of α-Globin Gene Triplication With β-thalassemia Heterozygous in Spain
por: Ropero, Paloma, et al.
Publicado: (2022)

Genomic organization and gene expression of the multiple globins in Atlantic cod: conservation of globin-flanking genes in chordates infers the origin of the vertebrate globin clusters
por: Wetten, Ola F, et al.
Publicado: (2010)

Engineering Globin Gene Expression
por: Davis, Rachael, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_v93dqridd8r1jhbn89pv3rsjjq