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Zika virus directly infects peripheral neurons and induces cell death
Zika virus (ZIKV)-infection is associated with neurological disorders of both the central and peripheral nervous systems (PNS), yet few studies have directly examined PNS-infection. Here we show that intraperitoneally or intraventricularly-injected ZIKV in the mouse could infect and impact periphera...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575960/ https://www.ncbi.nlm.nih.gov/pubmed/28758997 http://dx.doi.org/10.1038/nn.4612 |
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| author | Oh, Yohan Zhang, Feiran Wang, Yaqing Lee, Emily M. Choi, In Young Lim, Hotae Mirakhori, Fahimeh Li, Ronghua Huang, Luoxiu Xu, Tianlei Wu, Hao Li, Cui Qin, Cheng-Feng Wen, Zhexing Wu, Qing-Feng Tang, Hengli Xu, Zhiheng Jin, Peng Song, Hongjun Ming, Guo-li Lee, Gabsang |
| author_facet | Oh, Yohan Zhang, Feiran Wang, Yaqing Lee, Emily M. Choi, In Young Lim, Hotae Mirakhori, Fahimeh Li, Ronghua Huang, Luoxiu Xu, Tianlei Wu, Hao Li, Cui Qin, Cheng-Feng Wen, Zhexing Wu, Qing-Feng Tang, Hengli Xu, Zhiheng Jin, Peng Song, Hongjun Ming, Guo-li Lee, Gabsang |
| author_sort | Oh, Yohan |
| collection | PubMed |
| description | Zika virus (ZIKV)-infection is associated with neurological disorders of both the central and peripheral nervous systems (PNS), yet few studies have directly examined PNS-infection. Here we show that intraperitoneally or intraventricularly-injected ZIKV in the mouse could infect and impact peripheral neurons in vivo. Moreover, ZIKV productively infects stem cell-derived human neural crest cells and peripheral neurons in vitro, leading to increased cell death, transcriptional dysregulation and cell-type specific molecular pathology. |
| format | Online Article Text |
| id | pubmed-5575960 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-55759602018-01-31 Zika virus directly infects peripheral neurons and induces cell death Oh, Yohan Zhang, Feiran Wang, Yaqing Lee, Emily M. Choi, In Young Lim, Hotae Mirakhori, Fahimeh Li, Ronghua Huang, Luoxiu Xu, Tianlei Wu, Hao Li, Cui Qin, Cheng-Feng Wen, Zhexing Wu, Qing-Feng Tang, Hengli Xu, Zhiheng Jin, Peng Song, Hongjun Ming, Guo-li Lee, Gabsang Nat Neurosci Article Zika virus (ZIKV)-infection is associated with neurological disorders of both the central and peripheral nervous systems (PNS), yet few studies have directly examined PNS-infection. Here we show that intraperitoneally or intraventricularly-injected ZIKV in the mouse could infect and impact peripheral neurons in vivo. Moreover, ZIKV productively infects stem cell-derived human neural crest cells and peripheral neurons in vitro, leading to increased cell death, transcriptional dysregulation and cell-type specific molecular pathology. 2017-07-31 2017-09 /pmc/articles/PMC5575960/ /pubmed/28758997 http://dx.doi.org/10.1038/nn.4612 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Oh, Yohan Zhang, Feiran Wang, Yaqing Lee, Emily M. Choi, In Young Lim, Hotae Mirakhori, Fahimeh Li, Ronghua Huang, Luoxiu Xu, Tianlei Wu, Hao Li, Cui Qin, Cheng-Feng Wen, Zhexing Wu, Qing-Feng Tang, Hengli Xu, Zhiheng Jin, Peng Song, Hongjun Ming, Guo-li Lee, Gabsang Zika virus directly infects peripheral neurons and induces cell death |
| title | Zika virus directly infects peripheral neurons and induces cell death |
| title_full | Zika virus directly infects peripheral neurons and induces cell death |
| title_fullStr | Zika virus directly infects peripheral neurons and induces cell death |
| title_full_unstemmed | Zika virus directly infects peripheral neurons and induces cell death |
| title_short | Zika virus directly infects peripheral neurons and induces cell death |
| title_sort | zika virus directly infects peripheral neurons and induces cell death |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575960/ https://www.ncbi.nlm.nih.gov/pubmed/28758997 http://dx.doi.org/10.1038/nn.4612 |
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