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IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1

The gene encoding the Insulin-like Growth Factor 2 mRNA binding protein 2/IMP2 is amplified and overexpressed in many human cancers, accompanied by a poorer prognosis. Mice lacking IMP2 exhibit a longer lifespan and a reduced tumor burden at old age. Herein we show in a diverse array of human cancer...

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Detalles Bibliográficos
Autores principales:	Dai, Ning, Ji, Fei, Wright, Jason, Minichiello, Liliana, Sadreyev, Ruslan, Avruch, Joseph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576481/ https://www.ncbi.nlm.nih.gov/pubmed/28753127 http://dx.doi.org/10.7554/eLife.27155

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