Hypermethylation of the non-imprinted maternal MEG3 and paternal MEST alleles is highly variable among normal individuals

Imprinted genes show parent-specific activity (functional haploidy), which makes them particularly vulnerable to epigenetic dysregulation. Here we studied the methylation profiles of oppositely imprinted genes at single DNA molecule resolution by two independent parental allele-specific deep bisulfi...

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Detalles Bibliográficos
Autores principales: Haertle, Larissa, Maierhofer, Anna, Böck, Julia, Lehnen, Harald, Böttcher, Yvonne, Blüher, Matthias, Schorsch, Martin, Potabattula, Ramya, El Hajj, Nady, Appenzeller, Silke, Haaf, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576652/
https://www.ncbi.nlm.nih.gov/pubmed/28854270
http://dx.doi.org/10.1371/journal.pone.0184030

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