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Therapeutic time window for conivaptan treatment against stroke-evoked brain edema and blood-brain barrier disruption in mice

BACKGROUND: Ischemic stroke is often complicated by brain edema, disruption of blood-brain barrier (BBB), and uncontrolled release of arginine-vasopressin (AVP). Conivaptan, a V1a and V2 receptor antagonist, reduces brain edema and minimizes damage to the blood-brain barrier after stroke. Most strok...

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Detalles Bibliográficos
Autores principales:	Zeynalov, Emil, Jones, Susan M., Elliott, J. Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576654/ https://www.ncbi.nlm.nih.gov/pubmed/28854286 http://dx.doi.org/10.1371/journal.pone.0183985

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