Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

We recently developed base editing, the programmable conversion of target C:G base pairs to T:A without inducing double-stranded DNA breaks (DSBs) or requiring homology-directed repair using engineered fusions of Cas9 variants and cytidine deaminases. Over the past year, the third-generation base ed...

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Detalles Bibliográficos
Autores principales: Komor, Alexis C., Zhao, Kevin T., Packer, Michael S., Gaudelli, Nicole M., Waterbury, Amanda L., Koblan, Luke W., Kim, Y. Bill, Badran, Ahmed H., Liu, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2017
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576876/
https://www.ncbi.nlm.nih.gov/pubmed/28875174
http://dx.doi.org/10.1126/sciadv.aao4774

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