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Type III CRISPR-Cas systems can provide redundancy to counteract viral escape from type I systems

CRISPR-Cas-mediated defense utilizes information stored as spacers in CRISPR arrays to defend against genetic invaders. We define the mode of target interference and role in antiviral defense for two CRISPR-Cas systems in Marinomonas mediterranea. One system (type I-F) targets DNA. A second system (...

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Detalles Bibliográficos
Autores principales:	Silas, Sukrit, Lucas-Elio, Patricia, Jackson, Simon A, Aroca-Crevillén, Alejandra, Hansen, Loren L, Fineran, Peter C, Fire, Andrew Z, Sánchez-Amat, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Microbiology and Infectious Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576922/ https://www.ncbi.nlm.nih.gov/pubmed/28826484 http://dx.doi.org/10.7554/eLife.27601

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