The Functional Roles of the MDM2 Splice Variants P2-MDM2-10 and MDM2-∆5 in Breast Cancer Cells

BACKGROUND: MDM2 is a negative regulator of p53 and is upregulated in numerous human cancers. While different MDM2 splice variants have been observed in both normal tissues and malignant cells, their functions are poorly understood. METHODS: We evaluated the effect of MDM2 splice variants by overexp...

Descripción completa

Detalles Bibliográficos
Autores principales: Huun, Johanna, Gansmo, Liv B., Mannsåker, Bård, Iversen, Gjertrud T., Sommerfelt-Pettersen, Jan, Øvrebø, Jan Inge, Lønning, Per E., Knappskog, Stian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2017
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5576977/
https://www.ncbi.nlm.nih.gov/pubmed/28844019
http://dx.doi.org/10.1016/j.tranon.2017.07.006

Ejemplares similares

Ejemplares similares