Generalized Status Epilepticus in a Patient with Acute-onset Type 1 Diabetes Mellitus Associated with Severe Kidney Dysfunction: A Case Report and Literature Review

A 65-year-old Japanese man with advanced chronic kidney disease (CKD) developed acute-onset type 1 diabetes mellitus (T1D) that was associated with severe acute kidney injury and was manifested by generalized tonic-clonic status epilepticus. His seizures resolved without recurrence after correcting...

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Autores principales: Ohara, Nobumasa, Koda, Ryo, Watanabe, Hirofumi, Iino, Noriaki, Ohashi, Kazumasa, Terajima, Kenshi, Ozawa, Tetsutaro, Ikeda, Yohei, Sekiguchi, Hiroshi, Ohashi, Hitomi, Yamaguchi, Seigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Internal Medicine 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577076/
https://www.ncbi.nlm.nih.gov/pubmed/28768970
http://dx.doi.org/10.2169/internalmedicine.56.8304
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author Ohara, Nobumasa
Koda, Ryo
Watanabe, Hirofumi
Iino, Noriaki
Ohashi, Kazumasa
Terajima, Kenshi
Ozawa, Tetsutaro
Ikeda, Yohei
Sekiguchi, Hiroshi
Ohashi, Hitomi
Yamaguchi, Seigo
author_facet Ohara, Nobumasa
Koda, Ryo
Watanabe, Hirofumi
Iino, Noriaki
Ohashi, Kazumasa
Terajima, Kenshi
Ozawa, Tetsutaro
Ikeda, Yohei
Sekiguchi, Hiroshi
Ohashi, Hitomi
Yamaguchi, Seigo
author_sort Ohara, Nobumasa
collection PubMed
description A 65-year-old Japanese man with advanced chronic kidney disease (CKD) developed acute-onset type 1 diabetes mellitus (T1D) that was associated with severe acute kidney injury and was manifested by generalized tonic-clonic status epilepticus. His seizures resolved without recurrence after correcting the diabetic ketoacidosis. Although hyperglycemia is an important cause of acute symptomatic seizure (ASS), patients with ketotic hyperglycemia develop ASS less frequently. In this T1D case with CKD, severe hyperglycemia in conjunction with other metabolic insults, such as uremia, hyponatremia, and hypocalcemia, probably provoked his seizure despite the severe ketonemia.
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spelling pubmed-55770762017-09-01 Generalized Status Epilepticus in a Patient with Acute-onset Type 1 Diabetes Mellitus Associated with Severe Kidney Dysfunction: A Case Report and Literature Review Ohara, Nobumasa Koda, Ryo Watanabe, Hirofumi Iino, Noriaki Ohashi, Kazumasa Terajima, Kenshi Ozawa, Tetsutaro Ikeda, Yohei Sekiguchi, Hiroshi Ohashi, Hitomi Yamaguchi, Seigo Intern Med Case Report A 65-year-old Japanese man with advanced chronic kidney disease (CKD) developed acute-onset type 1 diabetes mellitus (T1D) that was associated with severe acute kidney injury and was manifested by generalized tonic-clonic status epilepticus. His seizures resolved without recurrence after correcting the diabetic ketoacidosis. Although hyperglycemia is an important cause of acute symptomatic seizure (ASS), patients with ketotic hyperglycemia develop ASS less frequently. In this T1D case with CKD, severe hyperglycemia in conjunction with other metabolic insults, such as uremia, hyponatremia, and hypocalcemia, probably provoked his seizure despite the severe ketonemia. The Japanese Society of Internal Medicine 2017-08-01 /pmc/articles/PMC5577076/ /pubmed/28768970 http://dx.doi.org/10.2169/internalmedicine.56.8304 Text en Copyright © 2017 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/ The Internal Medicine is an Open Access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Ohara, Nobumasa
Koda, Ryo
Watanabe, Hirofumi
Iino, Noriaki
Ohashi, Kazumasa
Terajima, Kenshi
Ozawa, Tetsutaro
Ikeda, Yohei
Sekiguchi, Hiroshi
Ohashi, Hitomi
Yamaguchi, Seigo
Generalized Status Epilepticus in a Patient with Acute-onset Type 1 Diabetes Mellitus Associated with Severe Kidney Dysfunction: A Case Report and Literature Review
title Generalized Status Epilepticus in a Patient with Acute-onset Type 1 Diabetes Mellitus Associated with Severe Kidney Dysfunction: A Case Report and Literature Review
title_full Generalized Status Epilepticus in a Patient with Acute-onset Type 1 Diabetes Mellitus Associated with Severe Kidney Dysfunction: A Case Report and Literature Review
title_fullStr Generalized Status Epilepticus in a Patient with Acute-onset Type 1 Diabetes Mellitus Associated with Severe Kidney Dysfunction: A Case Report and Literature Review
title_full_unstemmed Generalized Status Epilepticus in a Patient with Acute-onset Type 1 Diabetes Mellitus Associated with Severe Kidney Dysfunction: A Case Report and Literature Review
title_short Generalized Status Epilepticus in a Patient with Acute-onset Type 1 Diabetes Mellitus Associated with Severe Kidney Dysfunction: A Case Report and Literature Review
title_sort generalized status epilepticus in a patient with acute-onset type 1 diabetes mellitus associated with severe kidney dysfunction: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577076/
https://www.ncbi.nlm.nih.gov/pubmed/28768970
http://dx.doi.org/10.2169/internalmedicine.56.8304
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