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The Genetic Origin of Short Tail in Endangered Korean Dog, DongGyeongi

The tail of many animal species is responsible for various physiological functions. The functional importance of tail may have brought tail-loss to attention in many evolutionary and developmental studies. To provide a better explanation for the loss of tail, the current study aims to identify the e...

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Autores principales: Yoo, DongAhn, Kim, Kwondo, Kim, Hyaekang, Cho, Seoae, Kim, Jin Nam, Lim, Dajeong, Choi, Seog-Gyu, Choi, Bong-Hwan, Kim, Heebal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577146/
https://www.ncbi.nlm.nih.gov/pubmed/28855671
http://dx.doi.org/10.1038/s41598-017-10106-6
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author Yoo, DongAhn
Kim, Kwondo
Kim, Hyaekang
Cho, Seoae
Kim, Jin Nam
Lim, Dajeong
Choi, Seog-Gyu
Choi, Bong-Hwan
Kim, Heebal
author_facet Yoo, DongAhn
Kim, Kwondo
Kim, Hyaekang
Cho, Seoae
Kim, Jin Nam
Lim, Dajeong
Choi, Seog-Gyu
Choi, Bong-Hwan
Kim, Heebal
author_sort Yoo, DongAhn
collection PubMed
description The tail of many animal species is responsible for various physiological functions. The functional importance of tail may have brought tail-loss to attention in many evolutionary and developmental studies. To provide a better explanation for the loss of tail, the current study aims to identify the evolutionary history and putative causal variants for the short tail in DongGyeongi (DG), an endangered dog breed, which is also the only dog in Korea that possesses a short tail. Whole genome sequencing was conducted on 22 samples of DG, followed by an investigation of population stratification with 10 other dog breeds. The genotypes, selective sweep and demography of DG were also investigated. As a result, we discovered the unique genetic structure of DG and suggested two possible ways in which the short tail phenotype developed. Moreover, this study suggested that selective sweep genes, ANKRD11 and ACVR2B may contribute to the reduction in tail length, and non-synonymous variant in the coding sequence of T gene and the CpG island variant of SFRP2 gene are the candidate causal variants for the tail-loss.
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spelling pubmed-55771462017-09-01 The Genetic Origin of Short Tail in Endangered Korean Dog, DongGyeongi Yoo, DongAhn Kim, Kwondo Kim, Hyaekang Cho, Seoae Kim, Jin Nam Lim, Dajeong Choi, Seog-Gyu Choi, Bong-Hwan Kim, Heebal Sci Rep Article The tail of many animal species is responsible for various physiological functions. The functional importance of tail may have brought tail-loss to attention in many evolutionary and developmental studies. To provide a better explanation for the loss of tail, the current study aims to identify the evolutionary history and putative causal variants for the short tail in DongGyeongi (DG), an endangered dog breed, which is also the only dog in Korea that possesses a short tail. Whole genome sequencing was conducted on 22 samples of DG, followed by an investigation of population stratification with 10 other dog breeds. The genotypes, selective sweep and demography of DG were also investigated. As a result, we discovered the unique genetic structure of DG and suggested two possible ways in which the short tail phenotype developed. Moreover, this study suggested that selective sweep genes, ANKRD11 and ACVR2B may contribute to the reduction in tail length, and non-synonymous variant in the coding sequence of T gene and the CpG island variant of SFRP2 gene are the candidate causal variants for the tail-loss. Nature Publishing Group UK 2017-08-30 /pmc/articles/PMC5577146/ /pubmed/28855671 http://dx.doi.org/10.1038/s41598-017-10106-6 Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yoo, DongAhn
Kim, Kwondo
Kim, Hyaekang
Cho, Seoae
Kim, Jin Nam
Lim, Dajeong
Choi, Seog-Gyu
Choi, Bong-Hwan
Kim, Heebal
The Genetic Origin of Short Tail in Endangered Korean Dog, DongGyeongi
title The Genetic Origin of Short Tail in Endangered Korean Dog, DongGyeongi
title_full The Genetic Origin of Short Tail in Endangered Korean Dog, DongGyeongi
title_fullStr The Genetic Origin of Short Tail in Endangered Korean Dog, DongGyeongi
title_full_unstemmed The Genetic Origin of Short Tail in Endangered Korean Dog, DongGyeongi
title_short The Genetic Origin of Short Tail in Endangered Korean Dog, DongGyeongi
title_sort genetic origin of short tail in endangered korean dog, donggyeongi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577146/
https://www.ncbi.nlm.nih.gov/pubmed/28855671
http://dx.doi.org/10.1038/s41598-017-10106-6
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