Cargando…

The Influence of Different Maternal Microbial Communities on the Development of Infant Gut and Oral Microbiota

Very few studies have analyzed how the composition of mother’s microbiota affects the development of infant’s gut and oral microbiota during the first months of life. Here, microbiota present in the mothers’ gut, vagina, breast milk, oral cavity, and mammary areola were compared with the gut and ora...

Descripción completa

Detalles Bibliográficos
Autores principales: Drell, Tiina, Štšepetova, Jelena, Simm, Jaak, Rull, Kristiina, Aleksejeva, Aira, Antson, Anne, Tillmann, Vallo, Metsis, Madis, Sepp, Epp, Salumets, Andres, Mändar, Reet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577157/
https://www.ncbi.nlm.nih.gov/pubmed/28855595
http://dx.doi.org/10.1038/s41598-017-09278-y
_version_ 1783260297519169536
author Drell, Tiina
Štšepetova, Jelena
Simm, Jaak
Rull, Kristiina
Aleksejeva, Aira
Antson, Anne
Tillmann, Vallo
Metsis, Madis
Sepp, Epp
Salumets, Andres
Mändar, Reet
author_facet Drell, Tiina
Štšepetova, Jelena
Simm, Jaak
Rull, Kristiina
Aleksejeva, Aira
Antson, Anne
Tillmann, Vallo
Metsis, Madis
Sepp, Epp
Salumets, Andres
Mändar, Reet
author_sort Drell, Tiina
collection PubMed
description Very few studies have analyzed how the composition of mother’s microbiota affects the development of infant’s gut and oral microbiota during the first months of life. Here, microbiota present in the mothers’ gut, vagina, breast milk, oral cavity, and mammary areola were compared with the gut and oral microbiota of their infants over the first six months following birth. Samples were collected from the aforementioned body sites from seven mothers and nine infants at three different time points over a 6-month period. Each sample was analyzed with 16S rRNA gene sequencing. The gut microbiota of the infants harbored distinct microbial communities that had low similarity with the various maternal microbiota communities. In contrast, the oral microbiota of the infants exhibited high similarity with the microbiota of the mothers’ breast milk, mammary areola and mouth. These results demonstrate that constant contact between microbial communities increases their similarity. A majority of the operational taxonomic units in infant gut and oral microbiota were also shared with the mothers’ gut and oral communities, respectively. The disparity between the similarity and the proportion of the OTUs shared between infants’ and mothers’ gut microbiota might be related to lower diversity and therefore competition in infants’ gut microbiota.
format Online
Article
Text
id pubmed-5577157
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-55771572017-09-01 The Influence of Different Maternal Microbial Communities on the Development of Infant Gut and Oral Microbiota Drell, Tiina Štšepetova, Jelena Simm, Jaak Rull, Kristiina Aleksejeva, Aira Antson, Anne Tillmann, Vallo Metsis, Madis Sepp, Epp Salumets, Andres Mändar, Reet Sci Rep Article Very few studies have analyzed how the composition of mother’s microbiota affects the development of infant’s gut and oral microbiota during the first months of life. Here, microbiota present in the mothers’ gut, vagina, breast milk, oral cavity, and mammary areola were compared with the gut and oral microbiota of their infants over the first six months following birth. Samples were collected from the aforementioned body sites from seven mothers and nine infants at three different time points over a 6-month period. Each sample was analyzed with 16S rRNA gene sequencing. The gut microbiota of the infants harbored distinct microbial communities that had low similarity with the various maternal microbiota communities. In contrast, the oral microbiota of the infants exhibited high similarity with the microbiota of the mothers’ breast milk, mammary areola and mouth. These results demonstrate that constant contact between microbial communities increases their similarity. A majority of the operational taxonomic units in infant gut and oral microbiota were also shared with the mothers’ gut and oral communities, respectively. The disparity between the similarity and the proportion of the OTUs shared between infants’ and mothers’ gut microbiota might be related to lower diversity and therefore competition in infants’ gut microbiota. Nature Publishing Group UK 2017-08-30 /pmc/articles/PMC5577157/ /pubmed/28855595 http://dx.doi.org/10.1038/s41598-017-09278-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Drell, Tiina
Štšepetova, Jelena
Simm, Jaak
Rull, Kristiina
Aleksejeva, Aira
Antson, Anne
Tillmann, Vallo
Metsis, Madis
Sepp, Epp
Salumets, Andres
Mändar, Reet
The Influence of Different Maternal Microbial Communities on the Development of Infant Gut and Oral Microbiota
title The Influence of Different Maternal Microbial Communities on the Development of Infant Gut and Oral Microbiota
title_full The Influence of Different Maternal Microbial Communities on the Development of Infant Gut and Oral Microbiota
title_fullStr The Influence of Different Maternal Microbial Communities on the Development of Infant Gut and Oral Microbiota
title_full_unstemmed The Influence of Different Maternal Microbial Communities on the Development of Infant Gut and Oral Microbiota
title_short The Influence of Different Maternal Microbial Communities on the Development of Infant Gut and Oral Microbiota
title_sort influence of different maternal microbial communities on the development of infant gut and oral microbiota
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577157/
https://www.ncbi.nlm.nih.gov/pubmed/28855595
http://dx.doi.org/10.1038/s41598-017-09278-y
work_keys_str_mv AT drelltiina theinfluenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT stsepetovajelena theinfluenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT simmjaak theinfluenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT rullkristiina theinfluenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT aleksejevaaira theinfluenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT antsonanne theinfluenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT tillmannvallo theinfluenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT metsismadis theinfluenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT seppepp theinfluenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT salumetsandres theinfluenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT mandarreet theinfluenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT drelltiina influenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT stsepetovajelena influenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT simmjaak influenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT rullkristiina influenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT aleksejevaaira influenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT antsonanne influenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT tillmannvallo influenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT metsismadis influenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT seppepp influenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT salumetsandres influenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota
AT mandarreet influenceofdifferentmaternalmicrobialcommunitiesonthedevelopmentofinfantgutandoralmicrobiota