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Increased Risk of Atrial Fibrillation and Thromboembolism in Patients with Severe Psoriasis: a Nationwide Population-based Study

Psoriasis increases the risk of atrial fibrillation (AF) and thromboembolic events (TE). There is limited information on the effect of psoriasis severity on AF and TE. In this study, psoriasis patients were enrolled from the Korean National Insurance Service-National Sample Cohort (2004–2008). Diagn...

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Autores principales: Rhee, Tae-Min, Lee, Ji Hyun, Choi, Eue-Keun, Han, Kyung-Do, Lee, HyunJung, Park, Chan Soon, Hwang, Doyeon, Lee, So-Ryoung, Lim, Woo-Hyun, Kang, Si-Hyuck, Cha, Myung-Jin, Cho, Youngjin, Oh, Il-Young, Oh, Seil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577288/
https://www.ncbi.nlm.nih.gov/pubmed/28855659
http://dx.doi.org/10.1038/s41598-017-10556-y
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author Rhee, Tae-Min
Lee, Ji Hyun
Choi, Eue-Keun
Han, Kyung-Do
Lee, HyunJung
Park, Chan Soon
Hwang, Doyeon
Lee, So-Ryoung
Lim, Woo-Hyun
Kang, Si-Hyuck
Cha, Myung-Jin
Cho, Youngjin
Oh, Il-Young
Oh, Seil
author_facet Rhee, Tae-Min
Lee, Ji Hyun
Choi, Eue-Keun
Han, Kyung-Do
Lee, HyunJung
Park, Chan Soon
Hwang, Doyeon
Lee, So-Ryoung
Lim, Woo-Hyun
Kang, Si-Hyuck
Cha, Myung-Jin
Cho, Youngjin
Oh, Il-Young
Oh, Seil
author_sort Rhee, Tae-Min
collection PubMed
description Psoriasis increases the risk of atrial fibrillation (AF) and thromboembolic events (TE). There is limited information on the effect of psoriasis severity on AF and TE. In this study, psoriasis patients were enrolled from the Korean National Insurance Service-National Sample Cohort (2004–2008). Diagnosis and disease severity were determined from claims data. Newly diagnosed non-valvular AF and TE were identified during a 9.6-year follow-up. The effect of psoriasis severity on AF and TE was evaluated. We identified 13,385 psoriasis patients (1,947 with severe psoriasis). Severe psoriasis significantly increased the risk of AF (adjusted hazard ratio [HR(adjust)] 1.44 [95% confidence interval (CI) 1.14–1.82], p = 0.002) and TE (HR(adjust) 1.26 [95% CI 1.07–1.47], p = 0.005); mild psoriasis did not show any significant effects. Results were similar after propensity-score matching. Risk increments of AF and TE were prominent in patients with greater cardiovascular risk. A possible limitation of our study is that it has a retrospective design, and the effect of unmeasured confounders and risk of misclassification could bias the results. To conclude, our results showed that severe, but not mild, psoriasis significantly increased AF and TE risk. AF surveillance and active stroke prevention would be beneficial in such cases.
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spelling pubmed-55772882017-09-06 Increased Risk of Atrial Fibrillation and Thromboembolism in Patients with Severe Psoriasis: a Nationwide Population-based Study Rhee, Tae-Min Lee, Ji Hyun Choi, Eue-Keun Han, Kyung-Do Lee, HyunJung Park, Chan Soon Hwang, Doyeon Lee, So-Ryoung Lim, Woo-Hyun Kang, Si-Hyuck Cha, Myung-Jin Cho, Youngjin Oh, Il-Young Oh, Seil Sci Rep Article Psoriasis increases the risk of atrial fibrillation (AF) and thromboembolic events (TE). There is limited information on the effect of psoriasis severity on AF and TE. In this study, psoriasis patients were enrolled from the Korean National Insurance Service-National Sample Cohort (2004–2008). Diagnosis and disease severity were determined from claims data. Newly diagnosed non-valvular AF and TE were identified during a 9.6-year follow-up. The effect of psoriasis severity on AF and TE was evaluated. We identified 13,385 psoriasis patients (1,947 with severe psoriasis). Severe psoriasis significantly increased the risk of AF (adjusted hazard ratio [HR(adjust)] 1.44 [95% confidence interval (CI) 1.14–1.82], p = 0.002) and TE (HR(adjust) 1.26 [95% CI 1.07–1.47], p = 0.005); mild psoriasis did not show any significant effects. Results were similar after propensity-score matching. Risk increments of AF and TE were prominent in patients with greater cardiovascular risk. A possible limitation of our study is that it has a retrospective design, and the effect of unmeasured confounders and risk of misclassification could bias the results. To conclude, our results showed that severe, but not mild, psoriasis significantly increased AF and TE risk. AF surveillance and active stroke prevention would be beneficial in such cases. Nature Publishing Group UK 2017-08-30 /pmc/articles/PMC5577288/ /pubmed/28855659 http://dx.doi.org/10.1038/s41598-017-10556-y Text en © The Author(s) 2017 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Rhee, Tae-Min
Lee, Ji Hyun
Choi, Eue-Keun
Han, Kyung-Do
Lee, HyunJung
Park, Chan Soon
Hwang, Doyeon
Lee, So-Ryoung
Lim, Woo-Hyun
Kang, Si-Hyuck
Cha, Myung-Jin
Cho, Youngjin
Oh, Il-Young
Oh, Seil
Increased Risk of Atrial Fibrillation and Thromboembolism in Patients with Severe Psoriasis: a Nationwide Population-based Study
title Increased Risk of Atrial Fibrillation and Thromboembolism in Patients with Severe Psoriasis: a Nationwide Population-based Study
title_full Increased Risk of Atrial Fibrillation and Thromboembolism in Patients with Severe Psoriasis: a Nationwide Population-based Study
title_fullStr Increased Risk of Atrial Fibrillation and Thromboembolism in Patients with Severe Psoriasis: a Nationwide Population-based Study
title_full_unstemmed Increased Risk of Atrial Fibrillation and Thromboembolism in Patients with Severe Psoriasis: a Nationwide Population-based Study
title_short Increased Risk of Atrial Fibrillation and Thromboembolism in Patients with Severe Psoriasis: a Nationwide Population-based Study
title_sort increased risk of atrial fibrillation and thromboembolism in patients with severe psoriasis: a nationwide population-based study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577288/
https://www.ncbi.nlm.nih.gov/pubmed/28855659
http://dx.doi.org/10.1038/s41598-017-10556-y
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