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Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell

Molecular chaperones are pivotal in folding and degradation of the cellular proteome but their impact on the conformational dynamics of near-native membrane proteins with disease relevance remains unknown. Here we report the effect of chaperone activity on the functional conformation of the temperat...

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Detalles Bibliográficos
Autores principales:	Bagdany, Miklos, Veit, Guido, Fukuda, Ryosuke, Avramescu, Radu G., Okiyoneda, Tsukasa, Baaklini, Imad, Singh, Jay, Sovak, Guy, Xu, Haijin, Apaja, Pirjo M., Sattin, Sara, Beitel, Lenore K., Roldan, Ariel, Colombo, Giorgio, Balch, William, Young, Jason C., Lukacs, Gergely L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577305/ https://www.ncbi.nlm.nih.gov/pubmed/28855508 http://dx.doi.org/10.1038/s41467-017-00444-4

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