Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1/2, PI3Kδ/Akt and NFκB induction in a murine asthma model

The molecular mechanisms underlying asthma pathogenesis are poorly characterized. In this study, we investigated (1) whether Src mediates epidermal growth factor receptor (EGFR) transactivation; (2) if ERK1/2, PI3Kδ/Akt and NF-κB are signaling effectors downstream of Src/EGFR activation; and (3) if...

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Detalles Bibliográficos
Autores principales: El-Hashim, Ahmed Z., Khajah, Maitham A., Renno, Waleed M., Babyson, Rhema S., Uddin, Mohib, Benter, Ibrahim F., Ezeamuzie, Charles, Akhtar, Saghir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577320/
https://www.ncbi.nlm.nih.gov/pubmed/28855674
http://dx.doi.org/10.1038/s41598-017-09349-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577320/
https://www.ncbi.nlm.nih.gov/pubmed/28855674
http://dx.doi.org/10.1038/s41598-017-09349-0

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