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Collagen Complexity Spatially Defines Microregions of Total Tissue Pressure in Pancreatic Cancer

The poor efficacy of systemic cancer therapeutics in pancreatic ductal adenocarcinoma (PDAC) is partly attributed to deposition of collagen and hyaluronan, leading to interstitial hypertension collapsing blood and lymphatic vessels, limiting drug delivery. The intrinsic micro-regional interactions...

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Detalles Bibliográficos
Autores principales:	Nieskoski, Michael D., Marra, Kayla, Gunn, Jason R., Hoopes, P. Jack, Doyley, Marvin M., Hasan, Tayyaba, Trembly, B. Stuart, Pogue, Brian W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577321/ https://www.ncbi.nlm.nih.gov/pubmed/28855644 http://dx.doi.org/10.1038/s41598-017-10671-w

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