Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity

Despite the mechanisms for endogenous nitroxyl (HNO) production and action being incompletely understood, pharmacological donors show broad therapeutic promise and are in clinical trials. Mass spectrometry and site-directed mutagenesis showed that chemically distinct HNO donors 1-nitrosocyclohexyl a...

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Detalles Bibliográficos
Autores principales: Donzelli, Sonia, Goetz, Mara, Schmidt, Kjestine, Wolters, Markus, Stathopoulou, Konstantina, Diering, Simon, Prysyazhna, Oleksandra, Polat, Volkan, Scotcher, Jenna, Dees, Christian, Subramanian, Hariharan, Butt, Elke, Kamynina, Alisa, Schobesberger, Sophie, King, S. Bruce, Nikolaev, Viacheslav O., de Wit, Cor, Leichert, Lars I., Feil, Robert, Eaton, Philip, Cuello, Friederike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577323/
https://www.ncbi.nlm.nih.gov/pubmed/28855531
http://dx.doi.org/10.1038/s41598-017-09275-1

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