A Scalable Platform to Identify Fungal Secondary Metabolites and Their Gene Clusters

The genomes of filamentous fungi contain up to ~90 biosynthetic gene clusters (BGCs), encoding diverse secondary metabolites, an enormous reservoir of untapped chemical potential. However, recalcitrant genetics, cryptic expression, and unculturability prevent the systematic exploitation of these gen...

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Detalles Bibliográficos
Autores principales: Clevenger, Kenneth D., Bok, Jin Woo, Ye, Rosa, Miley, Galen P., Verdan, Maria H., Velk, Thomas, Chen, Cynthia, Yang, KaHoua, Robey, Matthew T., Gao, Peng, Lamprecht, Matthew, Thomas, Paul M., Islam, Md Nurul, Palmer, Jonathan M., Wu, Chengcang C., Keller, Nancy P., Kelleher, Neil L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577364/
https://www.ncbi.nlm.nih.gov/pubmed/28604695
http://dx.doi.org/10.1038/nchembio.2408

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