Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin

Clostridium perfringens iota-toxin and Clostridium botulinum C2 toxin are composed of two non-linked proteins, one being the enzymatic component and the other being the binding/translocation component. These latter components recognize specific receptors and oligomerize in plasma membrane lipid-raft...

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Detalles Bibliográficos
Autores principales: Takehara, Masaya, Takagishi, Teruhisa, Seike, Soshi, Oda, Masataka, Sakaguchi, Yoshihiko, Hisatsune, Junzo, Ochi, Sadayuki, Kobayashi, Keiko, Nagahama, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577581/
https://www.ncbi.nlm.nih.gov/pubmed/28800062
http://dx.doi.org/10.3390/toxins9080247
Descripción
Sumario:Clostridium perfringens iota-toxin and Clostridium botulinum C2 toxin are composed of two non-linked proteins, one being the enzymatic component and the other being the binding/translocation component. These latter components recognize specific receptors and oligomerize in plasma membrane lipid-rafts, mediating the uptake of the enzymatic component into the cytosol. Enzymatic components induce actin cytoskeleton disorganization through the ADP-ribosylation of actin and are responsible for cell rounding and death. This review focuses upon the recent advances in cellular internalization of clostridial binary toxins.

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