Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin

Clostridium perfringens iota-toxin and Clostridium botulinum C2 toxin are composed of two non-linked proteins, one being the enzymatic component and the other being the binding/translocation component. These latter components recognize specific receptors and oligomerize in plasma membrane lipid-raft...

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Autores principales: Takehara, Masaya, Takagishi, Teruhisa, Seike, Soshi, Oda, Masataka, Sakaguchi, Yoshihiko, Hisatsune, Junzo, Ochi, Sadayuki, Kobayashi, Keiko, Nagahama, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577581/
https://www.ncbi.nlm.nih.gov/pubmed/28800062
http://dx.doi.org/10.3390/toxins9080247
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author Takehara, Masaya
Takagishi, Teruhisa
Seike, Soshi
Oda, Masataka
Sakaguchi, Yoshihiko
Hisatsune, Junzo
Ochi, Sadayuki
Kobayashi, Keiko
Nagahama, Masahiro
author_facet Takehara, Masaya
Takagishi, Teruhisa
Seike, Soshi
Oda, Masataka
Sakaguchi, Yoshihiko
Hisatsune, Junzo
Ochi, Sadayuki
Kobayashi, Keiko
Nagahama, Masahiro
author_sort Takehara, Masaya
collection PubMed
description Clostridium perfringens iota-toxin and Clostridium botulinum C2 toxin are composed of two non-linked proteins, one being the enzymatic component and the other being the binding/translocation component. These latter components recognize specific receptors and oligomerize in plasma membrane lipid-rafts, mediating the uptake of the enzymatic component into the cytosol. Enzymatic components induce actin cytoskeleton disorganization through the ADP-ribosylation of actin and are responsible for cell rounding and death. This review focuses upon the recent advances in cellular internalization of clostridial binary toxins.
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spelling pubmed-55775812017-09-05 Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin Takehara, Masaya Takagishi, Teruhisa Seike, Soshi Oda, Masataka Sakaguchi, Yoshihiko Hisatsune, Junzo Ochi, Sadayuki Kobayashi, Keiko Nagahama, Masahiro Toxins (Basel) Review Clostridium perfringens iota-toxin and Clostridium botulinum C2 toxin are composed of two non-linked proteins, one being the enzymatic component and the other being the binding/translocation component. These latter components recognize specific receptors and oligomerize in plasma membrane lipid-rafts, mediating the uptake of the enzymatic component into the cytosol. Enzymatic components induce actin cytoskeleton disorganization through the ADP-ribosylation of actin and are responsible for cell rounding and death. This review focuses upon the recent advances in cellular internalization of clostridial binary toxins. MDPI 2017-08-11 /pmc/articles/PMC5577581/ /pubmed/28800062 http://dx.doi.org/10.3390/toxins9080247 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Takehara, Masaya
Takagishi, Teruhisa
Seike, Soshi
Oda, Masataka
Sakaguchi, Yoshihiko
Hisatsune, Junzo
Ochi, Sadayuki
Kobayashi, Keiko
Nagahama, Masahiro
Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin
title Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin
title_full Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin
title_fullStr Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin
title_full_unstemmed Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin
title_short Cellular Entry of Clostridium perfringens Iota-Toxin and Clostridium botulinum C2 Toxin
title_sort cellular entry of clostridium perfringens iota-toxin and clostridium botulinum c2 toxin
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577581/
https://www.ncbi.nlm.nih.gov/pubmed/28800062
http://dx.doi.org/10.3390/toxins9080247
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