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Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial

Botulinum toxin A is considered an important tool to control spasticity in children with cerebral palsy. Several factors are known to affect the efficacy of botulinum toxin, such as dosage, appropriate muscle selection and application, age, and accompanying therapy. A multicenter, double-blind, rand...

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Autores principales: Hong, Bo Young, Chang, Hyun Jung, Lee, Sang-Jee, Lee, Soyoung, Park, Joo Hyun, Kwon, Jeong-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577587/
https://www.ncbi.nlm.nih.gov/pubmed/28825663
http://dx.doi.org/10.3390/toxins9080253
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author Hong, Bo Young
Chang, Hyun Jung
Lee, Sang-Jee
Lee, Soyoung
Park, Joo Hyun
Kwon, Jeong-Yi
author_facet Hong, Bo Young
Chang, Hyun Jung
Lee, Sang-Jee
Lee, Soyoung
Park, Joo Hyun
Kwon, Jeong-Yi
author_sort Hong, Bo Young
collection PubMed
description Botulinum toxin A is considered an important tool to control spasticity in children with cerebral palsy. Several factors are known to affect the efficacy of botulinum toxin, such as dosage, appropriate muscle selection and application, age, and accompanying therapy. A multicenter, double-blind, randomized, prospective phase III clinical trial of botulinum toxin A for the treatment of dynamic equinus in 144 children with cerebral palsy was performed to compare the efficacies of letibotulinumtoxin A and onabotulinumtoxin A. Secondary analyses were performed to evaluate factors that affected the outcome, focusing on the number of times injections were repeated. Effectiveness was defined as a change of 2 or more in the physician’s rating scale. Multivariate regression analyses were performed with multiple variables. The first injection of botulinum toxin A significantly improved D subscale of Gross Motor Function Measure-88 scores at 3 months compared to repeated injections (p < 0.05). After 6 months, patients who had one injection or none before the study showed significantly better outcomes than those who had more than one injection in terms of observational gait scores.
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spelling pubmed-55775872017-09-05 Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial Hong, Bo Young Chang, Hyun Jung Lee, Sang-Jee Lee, Soyoung Park, Joo Hyun Kwon, Jeong-Yi Toxins (Basel) Article Botulinum toxin A is considered an important tool to control spasticity in children with cerebral palsy. Several factors are known to affect the efficacy of botulinum toxin, such as dosage, appropriate muscle selection and application, age, and accompanying therapy. A multicenter, double-blind, randomized, prospective phase III clinical trial of botulinum toxin A for the treatment of dynamic equinus in 144 children with cerebral palsy was performed to compare the efficacies of letibotulinumtoxin A and onabotulinumtoxin A. Secondary analyses were performed to evaluate factors that affected the outcome, focusing on the number of times injections were repeated. Effectiveness was defined as a change of 2 or more in the physician’s rating scale. Multivariate regression analyses were performed with multiple variables. The first injection of botulinum toxin A significantly improved D subscale of Gross Motor Function Measure-88 scores at 3 months compared to repeated injections (p < 0.05). After 6 months, patients who had one injection or none before the study showed significantly better outcomes than those who had more than one injection in terms of observational gait scores. MDPI 2017-08-21 /pmc/articles/PMC5577587/ /pubmed/28825663 http://dx.doi.org/10.3390/toxins9080253 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hong, Bo Young
Chang, Hyun Jung
Lee, Sang-Jee
Lee, Soyoung
Park, Joo Hyun
Kwon, Jeong-Yi
Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial
title Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial
title_full Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial
title_fullStr Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial
title_full_unstemmed Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial
title_short Efficacy of Repeated Botulinum Toxin Type A Injections for Spastic Equinus in Children with Cerebral Palsy—A Secondary Analysis of the Randomized Clinical Trial
title_sort efficacy of repeated botulinum toxin type a injections for spastic equinus in children with cerebral palsy—a secondary analysis of the randomized clinical trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577587/
https://www.ncbi.nlm.nih.gov/pubmed/28825663
http://dx.doi.org/10.3390/toxins9080253
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