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The Myriad Properties of Pasteurella multocida Lipopolysaccharide
Pasteurella multocida is a heterogeneous species that is a primary pathogen of many different vertebrates. This Gram-negative bacterium can cause a range of diseases, including fowl cholera in birds, haemorrhagic septicaemia in ungulates, atrophic rhinitis in swine, and lower respiratory tract infec...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577588/ https://www.ncbi.nlm.nih.gov/pubmed/28825691 http://dx.doi.org/10.3390/toxins9080254 |
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author | Harper, Marina Boyce, John Dallas |
author_facet | Harper, Marina Boyce, John Dallas |
author_sort | Harper, Marina |
collection | PubMed |
description | Pasteurella multocida is a heterogeneous species that is a primary pathogen of many different vertebrates. This Gram-negative bacterium can cause a range of diseases, including fowl cholera in birds, haemorrhagic septicaemia in ungulates, atrophic rhinitis in swine, and lower respiratory tract infections in cattle and pigs. One of the primary virulence factors of P. multocida is lipopolysaccharide (LPS). Recent work has shown that this crucial surface molecule shows significant structural variability across different P. multocida strains, with many producing LPS structures that are highly similar to the carbohydrate component of host glycoproteins. It is likely that this LPS mimicry of host molecules plays a major role in the survival of P. multocida in certain host niches. P. multocida LPS also plays a significant role in resisting the action of chicken cathelicidins, and is a strong stimulator of host immune responses. The inflammatory response to the endotoxic lipid A component is a major contributor to the pathogenesis of certain infections. Recent work has shown that vaccines containing killed bacteria give protection only against other strains with identical, or nearly identical, surface LPS structures. Conversely, live attenuated vaccines give protection that is broadly protective, and their efficacy is independent of LPS structure. |
format | Online Article Text |
id | pubmed-5577588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55775882017-09-05 The Myriad Properties of Pasteurella multocida Lipopolysaccharide Harper, Marina Boyce, John Dallas Toxins (Basel) Review Pasteurella multocida is a heterogeneous species that is a primary pathogen of many different vertebrates. This Gram-negative bacterium can cause a range of diseases, including fowl cholera in birds, haemorrhagic septicaemia in ungulates, atrophic rhinitis in swine, and lower respiratory tract infections in cattle and pigs. One of the primary virulence factors of P. multocida is lipopolysaccharide (LPS). Recent work has shown that this crucial surface molecule shows significant structural variability across different P. multocida strains, with many producing LPS structures that are highly similar to the carbohydrate component of host glycoproteins. It is likely that this LPS mimicry of host molecules plays a major role in the survival of P. multocida in certain host niches. P. multocida LPS also plays a significant role in resisting the action of chicken cathelicidins, and is a strong stimulator of host immune responses. The inflammatory response to the endotoxic lipid A component is a major contributor to the pathogenesis of certain infections. Recent work has shown that vaccines containing killed bacteria give protection only against other strains with identical, or nearly identical, surface LPS structures. Conversely, live attenuated vaccines give protection that is broadly protective, and their efficacy is independent of LPS structure. MDPI 2017-08-21 /pmc/articles/PMC5577588/ /pubmed/28825691 http://dx.doi.org/10.3390/toxins9080254 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Harper, Marina Boyce, John Dallas The Myriad Properties of Pasteurella multocida Lipopolysaccharide |
title | The Myriad Properties of Pasteurella multocida Lipopolysaccharide |
title_full | The Myriad Properties of Pasteurella multocida Lipopolysaccharide |
title_fullStr | The Myriad Properties of Pasteurella multocida Lipopolysaccharide |
title_full_unstemmed | The Myriad Properties of Pasteurella multocida Lipopolysaccharide |
title_short | The Myriad Properties of Pasteurella multocida Lipopolysaccharide |
title_sort | myriad properties of pasteurella multocida lipopolysaccharide |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577588/ https://www.ncbi.nlm.nih.gov/pubmed/28825691 http://dx.doi.org/10.3390/toxins9080254 |
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