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Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies
The phylum proteobacteria contains a wide array of Gram-negative marine bacteria. With recent advances in genomic sequencing, genome analysis, and analytical chemistry techniques, a whole host of information is being revealed about the primary and secondary metabolism of marine proteobacteria. This...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577590/ https://www.ncbi.nlm.nih.gov/pubmed/28762997 http://dx.doi.org/10.3390/md15080235 |
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author | Timmermans, Marshall L. Paudel, Yagya P. Ross, Avena C. |
author_facet | Timmermans, Marshall L. Paudel, Yagya P. Ross, Avena C. |
author_sort | Timmermans, Marshall L. |
collection | PubMed |
description | The phylum proteobacteria contains a wide array of Gram-negative marine bacteria. With recent advances in genomic sequencing, genome analysis, and analytical chemistry techniques, a whole host of information is being revealed about the primary and secondary metabolism of marine proteobacteria. This has led to the discovery of a growing number of medically relevant natural products, including novel leads for the treatment of multidrug-resistant Staphylococcus aureus (MRSA) and cancer. Of equal interest, marine proteobacteria produce natural products whose structure and biosynthetic mechanisms differ from those of their terrestrial and actinobacterial counterparts. Notable features of secondary metabolites produced by marine proteobacteria include halogenation, sulfur-containing heterocycles, non-ribosomal peptides, and polyketides with unusual biosynthetic logic. As advances are made in the technology associated with functional genomics, such as computational sequence analysis, targeted DNA manipulation, and heterologous expression, it has become easier to probe the mechanisms for natural product biosynthesis. This review will focus on genomics driven approaches to understanding the biosynthetic mechanisms for natural products produced by marine proteobacteria. |
format | Online Article Text |
id | pubmed-5577590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-55775902017-09-05 Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies Timmermans, Marshall L. Paudel, Yagya P. Ross, Avena C. Mar Drugs Review The phylum proteobacteria contains a wide array of Gram-negative marine bacteria. With recent advances in genomic sequencing, genome analysis, and analytical chemistry techniques, a whole host of information is being revealed about the primary and secondary metabolism of marine proteobacteria. This has led to the discovery of a growing number of medically relevant natural products, including novel leads for the treatment of multidrug-resistant Staphylococcus aureus (MRSA) and cancer. Of equal interest, marine proteobacteria produce natural products whose structure and biosynthetic mechanisms differ from those of their terrestrial and actinobacterial counterparts. Notable features of secondary metabolites produced by marine proteobacteria include halogenation, sulfur-containing heterocycles, non-ribosomal peptides, and polyketides with unusual biosynthetic logic. As advances are made in the technology associated with functional genomics, such as computational sequence analysis, targeted DNA manipulation, and heterologous expression, it has become easier to probe the mechanisms for natural product biosynthesis. This review will focus on genomics driven approaches to understanding the biosynthetic mechanisms for natural products produced by marine proteobacteria. MDPI 2017-08-01 /pmc/articles/PMC5577590/ /pubmed/28762997 http://dx.doi.org/10.3390/md15080235 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Timmermans, Marshall L. Paudel, Yagya P. Ross, Avena C. Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies |
title | Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies |
title_full | Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies |
title_fullStr | Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies |
title_full_unstemmed | Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies |
title_short | Investigating the Biosynthesis of Natural Products from Marine Proteobacteria: A Survey of Molecules and Strategies |
title_sort | investigating the biosynthesis of natural products from marine proteobacteria: a survey of molecules and strategies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577590/ https://www.ncbi.nlm.nih.gov/pubmed/28762997 http://dx.doi.org/10.3390/md15080235 |
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