Saccharomonopyrones A–C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490

Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new α-pyrones, saccharomonopyrones A–C (1–3). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomono...

Descripción completa

Detalles Bibliográficos
Autores principales: Yim, Chae-Yoon, Le, Tu Cam, Lee, Tae Gu, Yang, Inho, Choi, Hansol, Lee, Jusung, Kang, Kyung-Yun, Lee, Jin Sil, Lim, Kyung-Min, Yee, Sung-Tae, Kang, Heonjoong, Nam, Sang-Jip, Fenical, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577594/
https://www.ncbi.nlm.nih.gov/pubmed/28771166
http://dx.doi.org/10.3390/md15080239
Descripción
Sumario:Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new α-pyrones, saccharomonopyrones A–C (1–3). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (1) is the first α-pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl and a 6-alkyl side-chain within a 3,4,5,6-tetrasubstituted α-pyrone moiety. Saccharomonopyrone A exhibited weak antioxidant activity using a cation radical scavenging activity assay with an IC(50) value of 140 μM.

Ejemplares similares