Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069

Two new alkaloids, strepchazolins A (1) and B (2), together with a previously reported compound, streptazolin (3), were isolated from a marine actinomycete, Streptomyces chartreusis NA02069, collected in the Coast of Hainan Island, China. The structures of new compounds were determined by extensive...

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Detalles Bibliográficos
Autores principales: Yang, Cheng-Long, Wang, Yi-Shuang, Liu, Cheng-Li, Zeng, Ying-Jie, Cheng, Ping, Jiao, Rui-Hua, Bao, Shi-Xiang, Huang, Hui-Qin, Tan, Ren-Xiang, Ge, Hui-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577599/
https://www.ncbi.nlm.nih.gov/pubmed/28767052
http://dx.doi.org/10.3390/md15080244
Descripción
Sumario:Two new alkaloids, strepchazolins A (1) and B (2), together with a previously reported compound, streptazolin (3), were isolated from a marine actinomycete, Streptomyces chartreusis NA02069, collected in the Coast of Hainan Island, China. The structures of new compounds were determined by extensive NMR, mass spectroscopic and X-ray crystallographic analysis, as well as modified Mosher’s method. Compound 1 showed weak anti-Bacillus subtilis activity with the MIC value of 64.0 μM, and weak inhibitory activity against acetylcholinesterase (AChE) in vitro with IC(50) value of 50.6 μM, while its diastereoisomer, Compound 2, is almost inactive.

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