Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069

Two new alkaloids, strepchazolins A (1) and B (2), together with a previously reported compound, streptazolin (3), were isolated from a marine actinomycete, Streptomyces chartreusis NA02069, collected in the Coast of Hainan Island, China. The structures of new compounds were determined by extensive...

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Autores principales: Yang, Cheng-Long, Wang, Yi-Shuang, Liu, Cheng-Li, Zeng, Ying-Jie, Cheng, Ping, Jiao, Rui-Hua, Bao, Shi-Xiang, Huang, Hui-Qin, Tan, Ren-Xiang, Ge, Hui-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577599/
https://www.ncbi.nlm.nih.gov/pubmed/28767052
http://dx.doi.org/10.3390/md15080244
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author Yang, Cheng-Long
Wang, Yi-Shuang
Liu, Cheng-Li
Zeng, Ying-Jie
Cheng, Ping
Jiao, Rui-Hua
Bao, Shi-Xiang
Huang, Hui-Qin
Tan, Ren-Xiang
Ge, Hui-Ming
author_facet Yang, Cheng-Long
Wang, Yi-Shuang
Liu, Cheng-Li
Zeng, Ying-Jie
Cheng, Ping
Jiao, Rui-Hua
Bao, Shi-Xiang
Huang, Hui-Qin
Tan, Ren-Xiang
Ge, Hui-Ming
author_sort Yang, Cheng-Long
collection PubMed
description Two new alkaloids, strepchazolins A (1) and B (2), together with a previously reported compound, streptazolin (3), were isolated from a marine actinomycete, Streptomyces chartreusis NA02069, collected in the Coast of Hainan Island, China. The structures of new compounds were determined by extensive NMR, mass spectroscopic and X-ray crystallographic analysis, as well as modified Mosher’s method. Compound 1 showed weak anti-Bacillus subtilis activity with the MIC value of 64.0 μM, and weak inhibitory activity against acetylcholinesterase (AChE) in vitro with IC(50) value of 50.6 μM, while its diastereoisomer, Compound 2, is almost inactive.
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spelling pubmed-55775992017-09-05 Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069 Yang, Cheng-Long Wang, Yi-Shuang Liu, Cheng-Li Zeng, Ying-Jie Cheng, Ping Jiao, Rui-Hua Bao, Shi-Xiang Huang, Hui-Qin Tan, Ren-Xiang Ge, Hui-Ming Mar Drugs Article Two new alkaloids, strepchazolins A (1) and B (2), together with a previously reported compound, streptazolin (3), were isolated from a marine actinomycete, Streptomyces chartreusis NA02069, collected in the Coast of Hainan Island, China. The structures of new compounds were determined by extensive NMR, mass spectroscopic and X-ray crystallographic analysis, as well as modified Mosher’s method. Compound 1 showed weak anti-Bacillus subtilis activity with the MIC value of 64.0 μM, and weak inhibitory activity against acetylcholinesterase (AChE) in vitro with IC(50) value of 50.6 μM, while its diastereoisomer, Compound 2, is almost inactive. MDPI 2017-08-02 /pmc/articles/PMC5577599/ /pubmed/28767052 http://dx.doi.org/10.3390/md15080244 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yang, Cheng-Long
Wang, Yi-Shuang
Liu, Cheng-Li
Zeng, Ying-Jie
Cheng, Ping
Jiao, Rui-Hua
Bao, Shi-Xiang
Huang, Hui-Qin
Tan, Ren-Xiang
Ge, Hui-Ming
Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069
title Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069
title_full Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069
title_fullStr Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069
title_full_unstemmed Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069
title_short Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069
title_sort strepchazolins a and b: two new alkaloids from a marine streptomyces chartreusis na02069
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577599/
https://www.ncbi.nlm.nih.gov/pubmed/28767052
http://dx.doi.org/10.3390/md15080244
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