Marine Inspired 2-(5-Halo-1H-indol-3-yl)-N,N-dimethylethanamines as Modulators of Serotonin Receptors: An Example Illustrating the Power of Bromine as Part of the Uniquely Marine Chemical Space

In previous studies, we have isolated several marine indole alkaloids and evaluated them in the forced swim test (FST) and locomotor activity test, revealing their potential as antidepressant and sedative drug leads. Amongst the reported metabolites to display such activities was 5-bromo-N,N-dimethy...

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Detalles Bibliográficos
Autores principales: Ibrahim, Mohamed A., El-Alfy, Abir T., Ezel, Kelly, Radwan, Mohamed O., Shilabin, Abbas G., Kochanowska-Karamyan, Anna J., Abd-Alla, Howaida I., Otsuka, Masami, Hamann, Mark T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577603/
https://www.ncbi.nlm.nih.gov/pubmed/28792478
http://dx.doi.org/10.3390/md15080248

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