Two Furanosesterterpenoids from the Sponge Luffariella variabilis

Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations...

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Autores principales: Ahmadi, Peni, Higashi, Masahiro, de Voogd, Nicole J., Tanaka, Junichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577604/
https://www.ncbi.nlm.nih.gov/pubmed/28796183
http://dx.doi.org/10.3390/md15080249
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author Ahmadi, Peni
Higashi, Masahiro
de Voogd, Nicole J.
Tanaka, Junichi
author_facet Ahmadi, Peni
Higashi, Masahiro
de Voogd, Nicole J.
Tanaka, Junichi
author_sort Ahmadi, Peni
collection PubMed
description Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC(50) 1.0 µM against NBT-T2 cells.
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spelling pubmed-55776042017-09-05 Two Furanosesterterpenoids from the Sponge Luffariella variabilis Ahmadi, Peni Higashi, Masahiro de Voogd, Nicole J. Tanaka, Junichi Mar Drugs Article Two new sesterterpenoids, 1 and 2, were isolated from the sponge Luffariella variabilis. Their planar structures were characterized with spectroscopic analyses. The sole chiral center of compound 1 was elucidated as 12R by comparing observed and calculated optical rotation values. The configurations of compound 2 were determined by NMR and electronic circular dichroism (ECD) studies. Furthermore, compound 2 showed cytotoxicity at IC(50) 1.0 µM against NBT-T2 cells. MDPI 2017-08-10 /pmc/articles/PMC5577604/ /pubmed/28796183 http://dx.doi.org/10.3390/md15080249 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ahmadi, Peni
Higashi, Masahiro
de Voogd, Nicole J.
Tanaka, Junichi
Two Furanosesterterpenoids from the Sponge Luffariella variabilis
title Two Furanosesterterpenoids from the Sponge Luffariella variabilis
title_full Two Furanosesterterpenoids from the Sponge Luffariella variabilis
title_fullStr Two Furanosesterterpenoids from the Sponge Luffariella variabilis
title_full_unstemmed Two Furanosesterterpenoids from the Sponge Luffariella variabilis
title_short Two Furanosesterterpenoids from the Sponge Luffariella variabilis
title_sort two furanosesterterpenoids from the sponge luffariella variabilis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577604/
https://www.ncbi.nlm.nih.gov/pubmed/28796183
http://dx.doi.org/10.3390/md15080249
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