Copper-catalyzed oxidative C(sp(3))–H/C(sp(2))–H cross-coupling en route to carbocyclic rings

Copper-catalyzed selective coupling of C(sp(3))–H bonds with C(sp(2))–H bonds has been developed. An aniline module was used as a directing group to generate an aminyl radical, which selectively cleaves the secondary and tertiary C(sp(3))–H bonds via a 1,5-HAT process to forge six-membered carbocycl...

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Detalles Bibliográficos
Autores principales: Wang, Rui, Li, Yan, Jin, Ruo-Xing, Wang, Xi-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577718/
https://www.ncbi.nlm.nih.gov/pubmed/28966775
http://dx.doi.org/10.1039/c7sc00250e
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author Wang, Rui
Li, Yan
Jin, Ruo-Xing
Wang, Xi-Sheng
author_facet Wang, Rui
Li, Yan
Jin, Ruo-Xing
Wang, Xi-Sheng
author_sort Wang, Rui
collection PubMed
description Copper-catalyzed selective coupling of C(sp(3))–H bonds with C(sp(2))–H bonds has been developed. An aniline module was used as a directing group to generate an aminyl radical, which selectively cleaves the secondary and tertiary C(sp(3))–H bonds via a 1,5-HAT process to forge six-membered carbocyclic rings.
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spelling pubmed-55777182017-09-29 Copper-catalyzed oxidative C(sp(3))–H/C(sp(2))–H cross-coupling en route to carbocyclic rings Wang, Rui Li, Yan Jin, Ruo-Xing Wang, Xi-Sheng Chem Sci Chemistry Copper-catalyzed selective coupling of C(sp(3))–H bonds with C(sp(2))–H bonds has been developed. An aniline module was used as a directing group to generate an aminyl radical, which selectively cleaves the secondary and tertiary C(sp(3))–H bonds via a 1,5-HAT process to forge six-membered carbocyclic rings. Royal Society of Chemistry 2017-05-01 2017-03-15 /pmc/articles/PMC5577718/ /pubmed/28966775 http://dx.doi.org/10.1039/c7sc00250e Text en This journal is © The Royal Society of Chemistry 2017 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Wang, Rui
Li, Yan
Jin, Ruo-Xing
Wang, Xi-Sheng
Copper-catalyzed oxidative C(sp(3))–H/C(sp(2))–H cross-coupling en route to carbocyclic rings
title Copper-catalyzed oxidative C(sp(3))–H/C(sp(2))–H cross-coupling en route to carbocyclic rings
title_full Copper-catalyzed oxidative C(sp(3))–H/C(sp(2))–H cross-coupling en route to carbocyclic rings
title_fullStr Copper-catalyzed oxidative C(sp(3))–H/C(sp(2))–H cross-coupling en route to carbocyclic rings
title_full_unstemmed Copper-catalyzed oxidative C(sp(3))–H/C(sp(2))–H cross-coupling en route to carbocyclic rings
title_short Copper-catalyzed oxidative C(sp(3))–H/C(sp(2))–H cross-coupling en route to carbocyclic rings
title_sort copper-catalyzed oxidative c(sp(3))–h/c(sp(2))–h cross-coupling en route to carbocyclic rings
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577718/
https://www.ncbi.nlm.nih.gov/pubmed/28966775
http://dx.doi.org/10.1039/c7sc00250e
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AT jinruoxing coppercatalyzedoxidativecsp3hcsp2hcrosscouplingenroutetocarbocyclicrings
AT wangxisheng coppercatalyzedoxidativecsp3hcsp2hcrosscouplingenroutetocarbocyclicrings

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