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Cellular Reparative Mechanisms of Mesenchymal Stem Cells for Retinal Diseases

The use of multipotent mesenchymal stem cells (MSCs) has been reported as promising for the treatment of numerous degenerative disorders including the eye. In retinal degenerative diseases, MSCs exhibit the potential to regenerate into retinal neurons and retinal pigmented epithelial cells in both i...

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Detalles Bibliográficos
Autores principales: Ding, Suet Lee Shirley, Kumar, Suresh, Mok, Pooi Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577990/
https://www.ncbi.nlm.nih.gov/pubmed/28788088
http://dx.doi.org/10.3390/ijms18081406
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author Ding, Suet Lee Shirley
Kumar, Suresh
Mok, Pooi Ling
author_facet Ding, Suet Lee Shirley
Kumar, Suresh
Mok, Pooi Ling
author_sort Ding, Suet Lee Shirley
collection PubMed
description The use of multipotent mesenchymal stem cells (MSCs) has been reported as promising for the treatment of numerous degenerative disorders including the eye. In retinal degenerative diseases, MSCs exhibit the potential to regenerate into retinal neurons and retinal pigmented epithelial cells in both in vitro and in vivo studies. Delivery of MSCs was found to improve retinal morphology and function and delay retinal degeneration. In this review, we revisit the therapeutic role of MSCs in the diseased eye. Furthermore, we reveal the possible cellular mechanisms and identify the associated signaling pathways of MSCs in reversing the pathological conditions of various ocular disorders such as age-related macular degeneration (AMD), retinitis pigmentosa, diabetic retinopathy, and glaucoma. Current stem cell treatment can be dispensed as an independent cell treatment format or with the combination of other approaches. Hence, the improvement of the treatment strategy is largely subjected by our understanding of MSCs mechanism of action.
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spelling pubmed-55779902017-09-05 Cellular Reparative Mechanisms of Mesenchymal Stem Cells for Retinal Diseases Ding, Suet Lee Shirley Kumar, Suresh Mok, Pooi Ling Int J Mol Sci Review The use of multipotent mesenchymal stem cells (MSCs) has been reported as promising for the treatment of numerous degenerative disorders including the eye. In retinal degenerative diseases, MSCs exhibit the potential to regenerate into retinal neurons and retinal pigmented epithelial cells in both in vitro and in vivo studies. Delivery of MSCs was found to improve retinal morphology and function and delay retinal degeneration. In this review, we revisit the therapeutic role of MSCs in the diseased eye. Furthermore, we reveal the possible cellular mechanisms and identify the associated signaling pathways of MSCs in reversing the pathological conditions of various ocular disorders such as age-related macular degeneration (AMD), retinitis pigmentosa, diabetic retinopathy, and glaucoma. Current stem cell treatment can be dispensed as an independent cell treatment format or with the combination of other approaches. Hence, the improvement of the treatment strategy is largely subjected by our understanding of MSCs mechanism of action. MDPI 2017-07-28 /pmc/articles/PMC5577990/ /pubmed/28788088 http://dx.doi.org/10.3390/ijms18081406 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ding, Suet Lee Shirley
Kumar, Suresh
Mok, Pooi Ling
Cellular Reparative Mechanisms of Mesenchymal Stem Cells for Retinal Diseases
title Cellular Reparative Mechanisms of Mesenchymal Stem Cells for Retinal Diseases
title_full Cellular Reparative Mechanisms of Mesenchymal Stem Cells for Retinal Diseases
title_fullStr Cellular Reparative Mechanisms of Mesenchymal Stem Cells for Retinal Diseases
title_full_unstemmed Cellular Reparative Mechanisms of Mesenchymal Stem Cells for Retinal Diseases
title_short Cellular Reparative Mechanisms of Mesenchymal Stem Cells for Retinal Diseases
title_sort cellular reparative mechanisms of mesenchymal stem cells for retinal diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5577990/
https://www.ncbi.nlm.nih.gov/pubmed/28788088
http://dx.doi.org/10.3390/ijms18081406
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