Cargando…

Beneficial Effects of Galectin-3 Blockade in Vascular and Aortic Valve Alterations in an Experimental Pressure Overload Model

Galectin-3 (Gal-3) is involved in cardiovascular fibrosis and aortic valve (AV) calcification. We hypothesized that Gal-3 pharmacological inhibition with modified citrus pectin (MCP) could reduce aortic and AV remodeling in normotensive rats with pressure overload (PO). Six weeks after aortic constr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ibarrola, Jaime, Martínez-Martínez, Ernesto, Sádaba, J. Rafael, Arrieta, Vanessa, García-Peña, Amaia, Álvarez, Virginia, Fernández-Celis, Amaya, Gainza, Alicia, Rossignol, Patrick, Cachofeiro Ramos, Victoria, López-Andrés, Natalia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578054/ https://www.ncbi.nlm.nih.gov/pubmed/28758988 http://dx.doi.org/10.3390/ijms18081664

Ejemplares similares

Role for Galectin‐3 in Calcific Aortic Valve Stenosis
por: Sádaba, J. Rafael, et al.
Publicado: (2016)

Galectin-3 Blockade Reduces Renal Fibrosis in Two Normotensive Experimental Models of Renal Damage
por: Martinez-Martinez, Ernesto, et al.
Publicado: (2016)

Aldosterone Impairs Mitochondrial Function in Human Cardiac Fibroblasts via A-Kinase Anchor Protein 12
por: Ibarrola, Jaime, et al.
Publicado: (2018)

Activation of the Interleukin-33/ST2 Pathway Exerts Deleterious Effects in Myxomatous Mitral Valve Disease
por: Garcia-Pena, Amaia, et al.
Publicado: (2021)

Soluble St2 Induces Cardiac Fibroblast Activation and Collagen Synthesis via Neuropilin-1
por: Matilla, Lara, et al.
Publicado: (2020)

Beneficial Effects of Mineralocorticoid Receptor Antagonism on Myocardial Fibrosis in an Experimental Model of the Myxomatous Degeneration of the Mitral Valve
por: Ibarrola, Jaime, et al.
Publicado: (2020)

Targeting Fatty Acid-Binding Protein 4 Improves Pathologic Features of Aortic Stenosis
por: Garaikoetxea, Mattie, et al.
Publicado: (2022)

Sex-specific role of galectin-3 in aortic stenosis
por: Matilla, Lara, et al.
Publicado: (2023)

Sex-Differences in Aortic Stenosis: Mechanistic Insights and Clinical Implications
por: Matilla, Lara, et al.
Publicado: (2022)

Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis
por: Jover, Eva, et al.
Publicado: (2022)

Characterization of the sex-specific pattern of angiogenesis and lymphangiogenesis in aortic stenosis
por: Matilla, Lara, et al.
Publicado: (2022)

Myocardial Injury After Ischemia/Reperfusion Is Attenuated By Pharmacological Galectin-3 Inhibition
por: Ibarrola, Jaime, et al.
Publicado: (2019)

Differential Proteomics Identifies Reticulocalbin-3 as a Novel Negative Mediator of Collagen Production in Human Cardiac Fibroblasts
por: Martínez-Martínez, Ernesto, et al.
Publicado: (2017)

Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein
por: Jover, Eva, et al.
Publicado: (2021)

Soluble ST2 as a New Oxidative Stress and Inflammation Marker in Metabolic Syndrome
por: Roy, Ignacio, et al.
Publicado: (2023)

Influence of diabetes mellitus on the pathological profile of aortic stenosis: a sex-based approach
por: Martín-Núñez, Ernesto, et al.
Publicado: (2023)

Inhibition of galectin-3 ameliorates the consequences of cardiac lipotoxicity in a rat model of diet-induced obesity
por: Marín-Royo, Gema, et al.
Publicado: (2018)

Oxidative Stress in Obesity
por: Martínez-Martínez, Ernesto, et al.
Publicado: (2022)

A Role for Soluble ST2 in Vascular Remodeling Associated with Obesity in Rats
por: Martínez-Martínez, Ernesto, et al.
Publicado: (2013)

Aldosterone and Its Blockade: A Cardiovascular and Renal Perspective
por: Lahera, V., et al.
Publicado: (2006)

Fibrosis, the Bad Actor in Cardiorenal Syndromes: Mechanisms Involved
por: Delgado-Valero, Beatriz, et al.
Publicado: (2021)

The Interaction between Mitochondrial Oxidative Stress and Gut Microbiota in the Cardiometabolic Consequences in Diet-Induced Obese Rats
por: Ortega-Hernández, Adriana, et al.
Publicado: (2020)

Iron overload and liver cancer
por: Molina-Sánchez, Pedro, et al.
Publicado: (2019)

Varied Practice in Laparoscopy Training: Beneficial Learning Stimulation or Cognitive Overload?
por: Spruit, Edward N., et al.
Publicado: (2016)

T cell costimulation blockade blunts pressure overload-induced heart failure
por: Kallikourdis, Marinos, et al.
Publicado: (2017)

Galectin-3 Identifies a Subset of Macrophages With a Potential Beneficial Role in Atherosclerosis
por: Di Gregoli, Karina, et al.
Publicado: (2020)

Oxidative Stress and Vascular Damage in the Context of Obesity: The Hidden Guest
por: Martínez-Martínez, Ernesto, et al.
Publicado: (2021)

Iron Overload and Apoptosis of HL-1 Cardiomyocytes: Effects of Calcium Channel Blockade
por: Chen, Mei-pian, et al.
Publicado: (2014)

Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity
por: Zheng, Shuang, et al.
Publicado: (2023)

ENaC blockade in proteinuria‐associated extracellular fluid volume overload – effective but risky
por: Ray, Evan C.
Publicado: (2018)

Galectin-3 blockade suppresses the growth of cetuximab-resistant human oral squamous cell carcinoma
por: Yin, Peng, et al.
Publicado: (2021)

Antibody-mediated blockade for galectin-3 binding protein in tumor secretome abrogates PDAC metastasis
por: Choi, Yeon-Sook, et al.
Publicado: (2022)

Antifibrotic effect of novel neutrophil gelatinase-associated lipocalin inhibitors in cardiac and renal disease models
por: Bonnard, Benjamin, et al.
Publicado: (2021)

Beneficial Effect of N-Carbamylglutamate in a Neonatal Form of Multiple Acyl-CoA Dehydrogenase Deficiency
por: Stanescu, Sinziana, et al.
Publicado: (2020)

Association between Galectin Levels and Neurodegenerative Diseases: Systematic Review and Meta-Analysis
por: Ramos-Martínez, Edgar, et al.
Publicado: (2022)

Purification of Recombinant Galectins Expressed in Bacteria
por: Prato, Cecilia Arahí, et al.
Publicado: (2020)

Mitochondrial Oxidative Stress Induces Cardiac Fibrosis in Obese Rats through Modulation of Transthyretin
por: Martínez-Martínez, Ernesto, et al.
Publicado: (2022)

Placental Expression Patterns of Galectin-1, Galectin-2, Galectin-3 and Galectin-13 in Cases of Intrauterine Growth Restriction (IUGR)
por: Hutter, Stefan, et al.
Publicado: (2016)

Chronic beta-adrenergic blockade prevents volume overload-induced re-localization and oxidation of soluble guanylyl cyclase
por: Liu, Yuchuan, et al.
Publicado: (2013)

Galectins Differentially Regulate the Surface Glycosylation of Human Monocytes
por: AbuSamra, Dina B., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_lg8o07skvf797sgs9pmngrifi9