Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their de...

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Detalles Bibliográficos
Autores principales: Ni, Shuaijian, Yao, Houzong, Wang, Lili, Lu, Jun, Jiang, Feng, Lu, Aiping, Zhang, Ge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578073/
https://www.ncbi.nlm.nih.gov/pubmed/28767098
http://dx.doi.org/10.3390/ijms18081683
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author Ni, Shuaijian
Yao, Houzong
Wang, Lili
Lu, Jun
Jiang, Feng
Lu, Aiping
Zhang, Ge
author_facet Ni, Shuaijian
Yao, Houzong
Wang, Lili
Lu, Jun
Jiang, Feng
Lu, Aiping
Zhang, Ge
author_sort Ni, Shuaijian
collection PubMed
description Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics.
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spelling pubmed-55780732017-09-05 Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes Ni, Shuaijian Yao, Houzong Wang, Lili Lu, Jun Jiang, Feng Lu, Aiping Zhang, Ge Int J Mol Sci Review Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their development as drug candidates for therapeutic applications. In this review, we will discuss methods to conquer these challenges and highlight recent developments of chemical modifications and technological advances that may enable early aptamers to be translated into clinical therapeutics. MDPI 2017-08-02 /pmc/articles/PMC5578073/ /pubmed/28767098 http://dx.doi.org/10.3390/ijms18081683 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ni, Shuaijian
Yao, Houzong
Wang, Lili
Lu, Jun
Jiang, Feng
Lu, Aiping
Zhang, Ge
Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes
title Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes
title_full Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes
title_fullStr Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes
title_full_unstemmed Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes
title_short Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes
title_sort chemical modifications of nucleic acid aptamers for therapeutic purposes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578073/
https://www.ncbi.nlm.nih.gov/pubmed/28767098
http://dx.doi.org/10.3390/ijms18081683
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