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Chemical Modifications of Nucleic Acid Aptamers for Therapeutic Purposes

Nucleic acid aptamers have minimal immunogenicity, high chemical synthesis production, low cost and high chemical stability when compared with antibodies. However, the susceptibility to nuclease degradation, rapid excretion through renal filtration and insufficient binding affinity hindered their de...

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Detalles Bibliográficos
Autores principales:	Ni, Shuaijian, Yao, Houzong, Wang, Lili, Lu, Jun, Jiang, Feng, Lu, Aiping, Zhang, Ge
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578073/ https://www.ncbi.nlm.nih.gov/pubmed/28767098 http://dx.doi.org/10.3390/ijms18081683

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