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Intramitochondrial Ascorbic Acid Enhances the Formation of Mitochondrial Superoxide Induced by Peroxynitrite via a Ca(2+)-Independent Mechanism

Exposure of U937 cells to peroxynitrite promotes mitochondrial superoxide formation via a mechanism dependent on both inhibition of complex III and increased mitochondrial Ca(2+) accumulation. Otherwise inactive concentrations of the oxidant produced the same maximal effects in the presence of eithe...

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Detalles Bibliográficos
Autores principales:	Guidarelli, Andrea, Cerioni, Liana, Fiorani, Mara, Cantoni, Orazio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578076/ https://www.ncbi.nlm.nih.gov/pubmed/28767071 http://dx.doi.org/10.3390/ijms18081686

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