Rho-Kinase Blockade Attenuates Podocyte Apoptosis by Inhibiting the Notch Signaling Pathway in Diabetic Nephropathy

Podocyte apoptosis is a key process in the onset of diabetic nephropathy. A significant body of evidence shows that the Notch signaling pathway plays a central role in this process. We found that Rho-kinase mediates transforming growth factor β (TGF-β)-induced Notch ligand Jag1 expression. Important...

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Detalles Bibliográficos
Autores principales: Matoba, Keiichiro, Kawanami, Daiji, Nagai, Yosuke, Takeda, Yusuke, Akamine, Tomoyo, Ishizawa, Sho, Kanazawa, Yasushi, Yokota, Tamotsu, Utsunomiya, Kazunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578183/
https://www.ncbi.nlm.nih.gov/pubmed/28820432
http://dx.doi.org/10.3390/ijms18081795

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