Cargando…

FANCD2 and DNA Damage

Investigators have dedicated considerable effort to understanding the molecular basis underlying Fanconi Anemia (FA), a rare human genetic disease featuring an extremely high incidence of cancer and many congenital defects. Among those studies, FA group D2 protein (FANCD2) has emerged as the focal p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nepal, Manoj, Che, Raymond, Ma, Chi, Zhang, Jun, Fei, Peiwen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2017
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578191/ https://www.ncbi.nlm.nih.gov/pubmed/28825622 http://dx.doi.org/10.3390/ijms18081804

Ejemplares similares

TFG-maintaining stability of overlooked FANCD2 confers early DNA-damage response
por: Ma, Chi, et al.
Publicado: (2020)

Involvement of FANCD2 in Energy Metabolism via ATP5α
por: Jayabal, Panneerselvam, et al.
Publicado: (2017)

Recruitment of DNA polymerase eta by FANCD2 in the early response to DNA damage
por: Fu, Dechen, et al.
Publicado: (2013)

Overlooked FANCD2 variant encodes a promising, portent tumor suppressor, and alternative polyadenylation contributes to its expression
por: Han, Bing, et al.
Publicado: (2017)

Phosphorylation of FANCD2 Inhibits the FANCD2/FANCI Complex and Suppresses the Fanconi Anemia Pathway in the Absence of DNA Damage
por: Lopez-Martinez, David, et al.
Publicado: (2019)

In vitro FANCD2 monoubiquitination by HHR6 and hRad18
por: Pickering, Anna, et al.
Publicado: (2013)

A Hidden Role of the Inactivated FANCD2: Upregulating ΔNp63
por: Panneerselvam, Jayabal, et al.
Publicado: (2013)

FANCD2–FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair
por: Alcón, Pablo, et al.
Publicado: (2020)

The FANCD2–FANCI complex is recruited to DNA interstrand crosslinks before monoubiquitination of FANCD2
por: Liang, Chih-Chao, et al.
Publicado: (2016)

FANCI Regulates Recruitment of the FA Core Complex at Sites of DNA Damage Independently of FANCD2
por: Castella, Maria, et al.
Publicado: (2015)

Deubiquitination of FANCD2 Is Required for DNA Crosslink Repair
por: Oestergaard, Vibe H., et al.
Publicado: (2007)

Regulation of FANCD2 and FANCI monoubiquitination by their interaction and by DNA
por: Longerich, Simonne, et al.
Publicado: (2014)

FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ
por: Kondo, Natsuko, et al.
Publicado: (2011)

Fanconi anemia proteins FANCD2 and FANCI exhibit different DNA damage responses during S-phase
por: Sareen, Archana, et al.
Publicado: (2012)

A new look at molecular biology of breast cancer
por: Ma, Chi, et al.
Publicado: (2018)

DNA robustly stimulates FANCD2 monoubiquitylation in the complex with FANCI
por: Sato, Koichi, et al.
Publicado: (2012)

Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate
por: Panneerselvam, Jayabal, et al.
Publicado: (2014)

Correction: FANCD1/BRCA2 Plays Predominant Role in the Repair of DNA Damage Induced by ACNU or TMZ
por: Kondo, Natsuko, et al.
Publicado: (2011)

Association of Single-Nucleotide Polymorphisms in Monoubiquitinated FANCD2-DNA Damage Repair Pathway Genes With Breast Cancer in the Chinese Population
por: Chen, Fei-Yu, et al.
Publicado: (2018)

Binding of FANCI-FANCD2 Complex to RNA and R-Loops Stimulates Robust FANCD2 Monoubiquitination
por: Liang, Zhuobin, et al.
Publicado: (2019)

Biomarkers and Mechanisms of FANCD2 Function
por: Willers, Henning, et al.
Publicado: (2008)

Targeting FANCD2 for therapy sensitization
por: Shen, Changxian, et al.
Publicado: (2014)

Coordinate Nuclear Targeting of the FANCD2 and FANCI Proteins via a FANCD2 Nuclear Localization Signal
por: Boisvert, Rebecca A., et al.
Publicado: (2013)

FANCI Protein Binds to DNA and Interacts with FANCD2 to Recognize Branched Structures
por: Yuan, Fenghua, et al.
Publicado: (2009)

Cells Deficient in the Fanconi Anemia Protein FANCD2 are Hypersensitive to the Cytotoxicity and DNA Damage Induced by Coffee and Caffeic Acid
por: Burgos-Morón, Estefanía, et al.
Publicado: (2016)

The identification of FANCD2 DNA binding domains reveals nuclear localization sequences
por: Niraj, Joshi, et al.
Publicado: (2017)

In vivo analysis of FANCD2 recruitment at meiotic DNA breaks in Caenorhabditis elegans
por: Germoglio, Marcello, et al.
Publicado: (2020)

Fanconi Anemia complementation group C protein in metabolic disorders
por: Nepal, Manoj, et al.
Publicado: (2018)

DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response
por: Liang, Fengshan, et al.
Publicado: (2019)

The Genetic and Biochemical Basis of FANCD2 Monoubiquitination
por: Rajendra, Eeson, et al.
Publicado: (2014)

Structural insight into FANCI–FANCD2 monoubiquitination
por: Li, Landing, et al.
Publicado: (2020)

Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA
por: Rennie, Martin L, et al.
Publicado: (2020)

FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress
por: Yang, Yeran, et al.
Publicado: (2015)

ERCC1–XPF targeting to psoralen–DNA crosslinks depends on XPA and FANCD2
por: Sabatella, Mariangela, et al.
Publicado: (2019)

Conserved function of Drosophila Fancd2 monoubiquitination in response to double-strand DNA breaks
por: Clay, Delisa E, et al.
Publicado: (2022)

Allosteric mechanism for site-specific ubiquitination of FANCD2
por: Chaugule, Viduth K., et al.
Publicado: (2019)

A role for monoubiquitinated FANCD2 at telomeres in ALT cells
por: Fan, Qiang, et al.
Publicado: (2009)

Case-control analysis of truncating mutations in DNA damage response genes connects TEX15 and FANCD2 with hereditary breast cancer susceptibility
por: Mantere, Tuomo, et al.
Publicado: (2017)

Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2(−/−) Hematopoietic Stem and Progenitor Cells
por: Yoon, Young me, et al.
Publicado: (2016)

FANCD2 limits acetaldehyde‐induced genomic instability during DNA replication in esophageal keratinocytes
por: Peake, Jasmine D., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_q2f4649309ebr6nbqcvegr776j