Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation

Platelet-rich plasma is a current subject of studies on chronic wound healing therapy due to possible pro-angiogenic effects. Microvascular compromise represents the major component in radiogenic wound healing complications. The effects of platelet-rich plasma on irradiated cells of the cutaneous wo...

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Detalles Bibliográficos
Autores principales: Reinders, Yvonne, Felthaus, Oliver, Brockhoff, Gero, Pohl, Fabian, Ahrens, Norbert, Prantl, Lukas, Haubner, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578205/
https://www.ncbi.nlm.nih.gov/pubmed/28829358
http://dx.doi.org/10.3390/ijms18081819
Descripción
Sumario:Platelet-rich plasma is a current subject of studies on chronic wound healing therapy due to possible pro-angiogenic effects. Microvascular compromise represents the major component in radiogenic wound healing complications. The effects of platelet-rich plasma on irradiated cells of the cutaneous wound healing process are poorly understood so far. In this study, the interaction of endothelial cells and adipose-derived stem cells in conjunction with treatment with platelet-rich plasma is investigated in the context of radiation effects. Therefore, the expression of surface-marker CD90 and CD31 was determined. Moreover, cell proliferation and viability after external radiation was analyzed with and without treatment by platelet-rich plasma.

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