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Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia

All blood lineage cells are generated from hematopoietic stem cells (HSCs), which reside in bone marrow after birth. HSCs self-renew, proliferate, and differentiate into mature progeny under the control of local microenvironments including hematopoietic niche, which can deliver regulatory signals in...

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Detalles Bibliográficos
Autores principales: Mukaida, Naofumi, Tanabe, Yamato, Baba, Tomohisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578209/
https://www.ncbi.nlm.nih.gov/pubmed/28829353
http://dx.doi.org/10.3390/ijms18081824
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author Mukaida, Naofumi
Tanabe, Yamato
Baba, Tomohisa
author_facet Mukaida, Naofumi
Tanabe, Yamato
Baba, Tomohisa
author_sort Mukaida, Naofumi
collection PubMed
description All blood lineage cells are generated from hematopoietic stem cells (HSCs), which reside in bone marrow after birth. HSCs self-renew, proliferate, and differentiate into mature progeny under the control of local microenvironments including hematopoietic niche, which can deliver regulatory signals in the form of bound or secreted molecules and from physical cues such as oxygen tension and shear stress. Among these mediators, accumulating evidence indicates the potential involvement of several chemokines, particularly CXCL12, in the interaction between HSCs and bone marrow microenvironments. Fusion between breakpoint cluster region (BCR) and Abelson murine leukemia viral oncogene homolog (ABL)-1 gene gives rise to BCR-ABL protein with a constitutive tyrosine kinase activity and transforms HSCs and/or hematopoietic progenitor cells (HPCs) into disease-propagating leukemia stem cells (LSCs) in chronic myeloid leukemia (CML). LSCs can self-renew, proliferate, and differentiate under the influence of the signals delivered by bone marrow microenvironments including niche, as HSCs can. Thus, the interaction with bone marrow microenvironments is indispensable for the initiation, maintenance, and progression of CML. Moreover, the crosstalk between LSCs and bone marrow microenvironments can contribute to some instances of therapeutic resistance. Furthermore, evidence is accumulating to indicate the important roles of bone marrow microenvironment-derived chemokines. Hence, we will herein discuss the roles of chemokines in CML with a focus on bone marrow microenvironments.
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spelling pubmed-55782092017-09-05 Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia Mukaida, Naofumi Tanabe, Yamato Baba, Tomohisa Int J Mol Sci Review All blood lineage cells are generated from hematopoietic stem cells (HSCs), which reside in bone marrow after birth. HSCs self-renew, proliferate, and differentiate into mature progeny under the control of local microenvironments including hematopoietic niche, which can deliver regulatory signals in the form of bound or secreted molecules and from physical cues such as oxygen tension and shear stress. Among these mediators, accumulating evidence indicates the potential involvement of several chemokines, particularly CXCL12, in the interaction between HSCs and bone marrow microenvironments. Fusion between breakpoint cluster region (BCR) and Abelson murine leukemia viral oncogene homolog (ABL)-1 gene gives rise to BCR-ABL protein with a constitutive tyrosine kinase activity and transforms HSCs and/or hematopoietic progenitor cells (HPCs) into disease-propagating leukemia stem cells (LSCs) in chronic myeloid leukemia (CML). LSCs can self-renew, proliferate, and differentiate under the influence of the signals delivered by bone marrow microenvironments including niche, as HSCs can. Thus, the interaction with bone marrow microenvironments is indispensable for the initiation, maintenance, and progression of CML. Moreover, the crosstalk between LSCs and bone marrow microenvironments can contribute to some instances of therapeutic resistance. Furthermore, evidence is accumulating to indicate the important roles of bone marrow microenvironment-derived chemokines. Hence, we will herein discuss the roles of chemokines in CML with a focus on bone marrow microenvironments. MDPI 2017-08-22 /pmc/articles/PMC5578209/ /pubmed/28829353 http://dx.doi.org/10.3390/ijms18081824 Text en © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mukaida, Naofumi
Tanabe, Yamato
Baba, Tomohisa
Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia
title Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia
title_full Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia
title_fullStr Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia
title_full_unstemmed Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia
title_short Chemokines as a Conductor of Bone Marrow Microenvironment in Chronic Myeloid Leukemia
title_sort chemokines as a conductor of bone marrow microenvironment in chronic myeloid leukemia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578209/
https://www.ncbi.nlm.nih.gov/pubmed/28829353
http://dx.doi.org/10.3390/ijms18081824
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